Glioblastoma: pathology, molecular mechanisms and markers
K Aldape, G Zadeh, S Mansouri, G Reifenberger… - Acta …, 2015 - Springer
Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …
The definition of primary and secondary glioblastoma
H Ohgaki, P Kleihues - Clinical cancer research, 2013 - AACR
Glioblastoma is the most frequent and malignant brain tumor. The vast majority of
glioblastomas (∼ 90%) develop rapidly de novo in elderly patients, without clinical or …
glioblastomas (∼ 90%) develop rapidly de novo in elderly patients, without clinical or …
Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin
Purpose Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1 R132MUT) is
frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed …
frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed …
Molecular signatures classify astrocytic gliomas by IDH1 mutation status
G Toedt, S Barbus, M Wolter, J Felsberg… - … journal of cancer, 2011 - Wiley Online Library
To identify novel glioma‐associated pathomechanisms and molecular markers, we
performed an array‐based comparative genomic hybridization analysis of 131 diffuse …
performed an array‐based comparative genomic hybridization analysis of 131 diffuse …
The evolving role of molecular markers in the diagnosis and management of diffuse glioma
While the classification of diffuse gliomas has relied on the examination of morphologic
features supplemented with techniques such as immunohistochemistry, there is an …
features supplemented with techniques such as immunohistochemistry, there is an …
Genetics and epigenetics of glioblastoma: applications and overall incidence of IDH1 mutation
A Liu, C Hou, H Chen, X Zong, P Zong - Frontiers in oncology, 2016 - frontiersin.org
Glioblastoma is the most fatal brain cancer found in humans. Patients suffering from
glioblastoma have a dismal prognosis, with a median survival of 15 months. The tumor may …
glioblastoma have a dismal prognosis, with a median survival of 15 months. The tumor may …
Characterization of gliomas: from morphology to molecules
SP Ferris, JW Hofmann, DA Solomon, A Perry - Virchows Archiv, 2017 - Springer
This article reviews the histologic and molecular characterization of gliomas, including the
new “integrated diagnoses” of the World Health Organization Classification, 2016 edition …
new “integrated diagnoses” of the World Health Organization Classification, 2016 edition …
[HTML][HTML] Beyond IDH-mutation: emerging molecular diagnostic and prognostic features in adult diffuse gliomas
K Mirchia, TE Richardson - Cancers, 2020 - mdpi.com
Diffuse gliomas are among the most common adult central nervous system tumors with an
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis
Gliomas are a large and diverse group of primary brain tumors that include those that are
diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas …
diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas …
Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis
S Camelo-Piragua, M Jansen, A Ganguly, JCM Kim… - Acta …, 2010 - Springer
One of the most vexing issues in diagnostic neuropathology relates to the distinction of
diffuse astrocytomas (and other diffuse gliomas) from astrocytosis (gliosis) on biopsies …
diffuse astrocytomas (and other diffuse gliomas) from astrocytosis (gliosis) on biopsies …