Ice recrystallization inhibition by amino acids: The curious case of alpha-and beta-alanine

MT Warren, I Galpin, F Bachtiger… - The journal of …, 2022 - ACS Publications
Extremophiles produce macromolecules which inhibit ice recrystallization, but there is
increasing interest in discovering and developing small molecules that can modulate ice …

Molecular dynamics at the interface between ice and poly (vinyl alcohol) and ice recrystallization inhibition

L Weng, SL Stott, M Toner - Langmuir, 2017 - ACS Publications
Ice formation is a ubiquitous process that poses serious challenges for many areas. Nature
has evolved a variety of different mechanisms to regulate ice formation. For example, many …

Hydrogen-bonding and hydrophobic groups contribute equally to the binding of hyperactive antifreeze and ice-nucleating proteins to ice

A Hudait, Y Qiu, N Odendahl… - Journal of the American …, 2019 - ACS Publications
Hyperactive insect antifreeze proteins and bacterial ice-nucleating proteins are arguably the
most potent ice-binding molecules in nature. These highly effective proteins bind ice through …

Hydration Index A Better Parameter for Explaining Small Molecule Hydration in Inhibition of Ice Recrystallization

RY Tam, SS Ferreira, P Czechura… - Journal of the …, 2008 - ACS Publications
Several simple mono-and disaccharides have been assessed for their ability to inhibit ice
recrystallization. Two carbohydrates were found to be effective recrystallization inhibitors. d …

Spreading fully at the ice-water interface is required for high ice recrystallization inhibition activity

S Jin, L Yin, B Kong, S Wu, Z He, H Xue, Z Liu… - Science China …, 2019 - Springer
Although materials for ice recrystallization inhibition (IRI) are essential for the
cryopreservation of cells and tissues, there exists no guiding mechanism for the design of …

Enhancement of macromolecular ice recrystallization inhibition activity by exploiting depletion forces

T Ishibe, T Congdon, C Stubbs, M Hasan… - ACS Macro …, 2019 - ACS Publications
Antifreeze (glyco) proteins (AF (G) Ps) are potent inhibitors of ice recrystallization and may
have biotechnological applications. The most potent AF (G) Ps function at concentrations a …

Ice recrystallization inhibitors: from biological antifreezes to small molecules

CJ Capicciotti, M Doshi, RN Ben - Recent developments in the …, 2013 - books.google.com
Recrystallizationisaphenomenonthat is welldocumented in thegeologicaland metallurgical
literature. In metallurgy, the phenomenon can be formally defined as the process by which …

The atomistic details of the ice recrystallisation inhibition activity of PVA

F Bachtiger, TR Congdon, C Stubbs, MI Gibson… - Nature …, 2021 - nature.com
Understanding the ice recrystallisation inhibition (IRI) activity of antifreeze biomimetics is
crucial to the development of the next generation of cryoprotectants. In this work, we bring …

Polymer self-assembly induced enhancement of ice recrystallization inhibition

PG Georgiou, HL Marton, AN Baker… - Journal of the …, 2021 - ACS Publications
Ice binding proteins modulate ice nucleation/growth and have huge (bio) technological
potential. There are few synthetic materials that reproduce their function, and rational design …

Ice recrystallization in a solution of a cryoprotector and its inhibition by a protein: synchrotron X-ray diffraction study

B Zakharov, A Fisyuk, A Fitch, Y Watier… - Journal of …, 2016 - Elsevier
Ice formation and recrystallization is a key phenomenon in freezing and freeze-drying of
pharmaceuticals and biopharmaceuticals. In this investigation, high-resolution synchrotron X …