Cardiac lymphatics in health and disease

E Brakenhielm, K Alitalo - Nature Reviews Cardiology, 2019 - nature.com
The lymphatic vasculature, which accompanies the blood vasculature in most organs, is
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …

Cardiac lymphatics–a new avenue for therapeutics?

T Vuorio, A Tirronen, S Ylä-Herttuala - Trends in Endocrinology & …, 2017 - cell.com
Recent progress in lymphatic vessel biology and in novel imaging techniques has
established the importance of the lymphatic vasculature as part of the cardiovascular …

[HTML][HTML] The evolving cardiac lymphatic vasculature in development, repair and regeneration

K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Lymphatic system in cardiovascular medicine

A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction

O Henri, C Pouehe, M Houssari, L Galas, L Nicol… - Circulation, 2016 - Am Heart Assoc
Background—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic
malfunction causes edema. The heart has an extensive lymphatic network displaying a …

[PDF][PDF] Lymphatic vessels at the heart of the matter

V Angeli, NL Harvey - Cell Metabolism, 2015 - cell.com
Emergent research in the past decades has brought to light the importance of lymphatic
vessels in tissue homeostasis, immunity, metabolism, and inflammation. In Nature, Klotz et …

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week

E Brakenhielm, A González, J Díez - Journal of the American College of …, 2020 - jacc.org
The cardiac lymphatic network plays a key role in regulation of myocardial extracellular
volume and immune cell homeostasis. In different pathological conditions cardiac …

Impact of lymphangiogenesis on cardiac remodeling after ischemia and reperfusion injury

Y Shimizu, R Polavarapu, KL Eskla… - Journal of the …, 2018 - Am Heart Assoc
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system
that aids in the control of tissue pressure and edema formation. Although the lymphatic …

Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol‐rich and calcified atherosclerotic lesions

I Kholová, G Dragneva, P Čermáková… - European journal of …, 2011 - Wiley Online Library
Eur J Clin Invest 2011; 41 (5): 487–497 Abstract Background Despite the importance of
myocardial vasculature in many pathological conditions, little information is available about …

Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction

M Houssari, A Dumesnil, V Tardif, R Kivelä… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Lymphatics play an essential pathophysiological role in promoting fluid and
immune cell tissue clearance. Conversely, immune cells may influence lymphatic function …