Background Generation of suitable in vivo models is critical for understanding of processes
associated with development and progression of prostate cancer (CaP). Methods Lymph …

Prostatic carcinoma has proven extremely difficult to establish as cell lines or xenografts. In
this article, we describe a new series of prostate cancer xenografts propagated in athymic …

BACKGROUND The LNCaP cell line was originally isolated from the lymph node of a patient
with metastatic prostate cancer. Many cell lines have been derived from LNCaP by selective …

Objectives We report the isolation and characterization of a novel prostate cancer cell line
derived from a vertebral metastatic lesion, Vertebral-Cancer of the Prostate (VCaP). Methods …

BACKGROUND LNCaP and its derivative cell lines, which include C4‐2 (and the related C4‐
2B) and CL1, are used as models of prostate cancer. Unlike LNCaP, the other cell lines …

BACKGROUND Clinically, the lethal phenotypes of human prostate cancer are
characterized by their progression to androgen‐independence and their propensity to form …

Identification of the genes involved in prostate cancer (PCa) progression to a virulent and
androgen-independent (AI) form is a major focus in the field. cDNA microarray was used to …

The late stages of progression of prostate carcinoma are typically characterized by an
androgen-insensitive, rapidly proliferative state. Some late-stage tumors are composed …

Background Mortality in prostate cancer is primarily due to failure to cure hormone refractory
patients with metastatic disease. The present study focused on elucidating alterations in …

BACKGROUND The acquisition of an androgen‐independent phenotype is the most serious
issue of prostate cancer treatment. Although several experimental cell models have been …