Background In 1968 the first antenatal diagnosis of Down's syndrome was made and
screening on the basis of selecting women of advanced maternal age for amniocentesis was …

The sensitivity and specificity of maternal serum screening for Down syndrome with different
biochemical markers were evaluated. Detection rates with different combinations of maternal …

Objective To determine the value of serum screening for Down's syndrome at 8–14 weeks of
pregnancy using seven potential serum markers (alpha‐fetoprotein, unconjugated oestriol …

OBJECTIVES--To assess the implementation of antenatal screening for Down's syndrome in
practice, using individual risk estimates based on maternal age and the three serum …

Background. Approximately 35 percent of all cases of Down's syndrome in fetuses can be
detected by measuring maternal serum alpha-fetoprotein during the second trimester in the …

OBJECTIVE: Our purpose was to determine the feasibility of a first-trimester Down syndrome
screening protocol including free β-human chorionic gonadotropin and pregnancy …

The value of measuring the separate sub‐units of human chorionic gonadotrophin (free α‐
hCG and free β‐hCG) instead of total hCG together with alpha‐fetoprotein (AFP) and …

Objective To investigate the effect of using a routine ultrasound estimate of gestational age
and maternal weight adjustment on maternal serum alpha‐fetoprotein (AFP), unconjugated …

Over a 2‐year period from January 1991 to December 1992, second‐trimester maternal
serum screening for Down's syndrome using alpha‐fetoprotein (aFP), human chorionic …

Objective: To test the efficacy of a screening protocol using a combination of maternal age
plus three biochemical markers—maternal serum alpha-fetoprotein (MSAFP), hCG, and …