Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and
neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated …

Senile plaques composed of Aβ peptides are a histopathological hallmark of Alzheimer
disease (AD). A role for Aβ in the etiology of AD has been argued from analysis of mutations …

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological
hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid …

Alzheimer's disease (AD) brains display A beta (Aβ) plaques, inflammatory changes and
neurofibrillary tangles (NFTs). Converging evidence suggests a neuronal origin of Aβ. We …

Plaques are a defining neuropathological hallmark of Alzheimer's disease (AD) and the
major constituent of plaques, the β-amyloid peptide (Aβ), is considered to play an important …

It is widely accepted that Aβ plays a pivotal role in the pathogenesis of Alzheimer's disease
(AD)[27]. Attention has been focused mainly on how extracellular Aβ exerts its effects on …

Neuropil deposition of β‐amyloid peptides Aβ40 and Aβ42 is believed to be the key event in
the neurodegenerative processes of Alzheimer's disease (AD). Since Aβ seems to carry a …

According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …

Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …

For approximately 80 years following Alzheimer's description of the disease that bears his
name, a gulf divided researchers who believed that extracellular deposits of the amyloid β …