[HTML][HTML] Intraneuronal Aβ42 accumulation in human brain
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and
neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated …
neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated …
Intracellular APP processing and Aβ production in Alzheimer disease
Senile plaques composed of Aβ peptides are a histopathological hallmark of Alzheimer
disease (AD). A role for Aβ in the etiology of AD has been argued from analysis of mutations …
disease (AD). A role for Aβ in the etiology of AD has been argued from analysis of mutations …
Plaque formation and the intraneuronal accumulation of β‐amyloid in Alzheimer's disease
RH Takahashi, T Nagao, GK Gouras - Pathology international, 2017 - Wiley Online Library
Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological
hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid …
hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid …
Intraneuronal Aβ42 accumulation in Down syndrome brain
C Mori, ET Spooner, KE Wisniewski, TM Wisniewski… - Amyloid, 2002 - Taylor & Francis
Alzheimer's disease (AD) brains display A beta (Aβ) plaques, inflammatory changes and
neurofibrillary tangles (NFTs). Converging evidence suggests a neuronal origin of Aβ. We …
neurofibrillary tangles (NFTs). Converging evidence suggests a neuronal origin of Aβ. We …
Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease
GK Gouras, CG Almeida, RH Takahashi - Neurobiology of aging, 2005 - Elsevier
Plaques are a defining neuropathological hallmark of Alzheimer's disease (AD) and the
major constituent of plaques, the β-amyloid peptide (Aβ), is considered to play an important …
major constituent of plaques, the β-amyloid peptide (Aβ), is considered to play an important …
Apoptotic neurons in Alzheimer's disease frequently show intracellular Aβ42 labeling
DH Chui, E Dobo, T Makifuchi… - Journal of …, 2001 - content.iospress.com
It is widely accepted that Aβ plays a pivotal role in the pathogenesis of Alzheimer's disease
(AD)[27]. Attention has been focused mainly on how extracellular Aβ exerts its effects on …
(AD)[27]. Attention has been focused mainly on how extracellular Aβ exerts its effects on …
Intraneuronal APP/Aβ trafficking and plaque formation in β‐amyloid precursor protein and presenilin‐1 transgenic mice
O Wirths, G Multhaup, C Czech, N Feldmann… - Brain …, 2002 - Wiley Online Library
Neuropil deposition of β‐amyloid peptides Aβ40 and Aβ42 is believed to be the key event in
the neurodegenerative processes of Alzheimer's disease (AD). Since Aβ seems to carry a …
the neurodegenerative processes of Alzheimer's disease (AD). Since Aβ seems to carry a …
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
C Schmitz, BPF Rutten, A Pielen, S Schäfer… - The American journal of …, 2004 - Elsevier
According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …
driving force in Alzheimer's disease pathogenesis. Despite the development of many …
Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in …
H Oakley, SL Cole, S Logan, E Maus… - Journal of …, 2006 - Soc Neuroscience
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …
The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
S Gandy - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
For approximately 80 years following Alzheimer's description of the disease that bears his
name, a gulf divided researchers who believed that extracellular deposits of the amyloid β …
name, a gulf divided researchers who believed that extracellular deposits of the amyloid β …