Connecting the mechanisms of tumor sex differences with cancer therapy

H Li, W Jiang, S Liu, M Yang, S Chen, Y Pan… - Molecular and Cellular …, 2024 - Springer
Sex differences in cancer incidence and survival are constant and pronounced globally,
across all races and all age groups of cancer types. In 2016, after the National Institutes of …

Genome-wide sex and gender differences in cancer

CM Lopes-Ramos, J Quackenbush… - Frontiers in oncology, 2020 - frontiersin.org
Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Sex differences in cancer mechanisms

JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

[HTML][HTML] Sex differences in cancer: epidemiology, genetics and therapy

HI Kim, H Lim, A Moon - Biomolecules & therapeutics, 2018 - ncbi.nlm.nih.gov
The incidence and mortality of various cancers are associated with sex-specific disparities.
Sex differences in cancer epidemiology are one of the most significant findings. Men are …

[HTML][HTML] Sex disparities in cancer

Y Zhu, X Shao, X Wang, L Liu, H Liang - Cancer letters, 2019 - Elsevier
Sex is a key biological factor affecting the development of many cancer types. There are
considerable differences between male and female subpopulations in terms of cancer …

Gender dimorphism creates divergent cancer susceptibilities

F Cheng - Trends in Cancer, 2016 - cell.com
To date, the cellular and molecular mechanisms underlying sexual dimorphism in the
incidence, prognosis, and treatment responses of cancer remain unclear. In a recent article …

Comprehensive characterization of molecular differences in cancer between male and female patients

Y Yuan, L Liu, H Chen, Y Wang, Y Xu, H Mao, J Li… - Cancer cell, 2016 - cell.com
An individual's sex has been long recognized as a key factor affecting cancer incidence,
prognosis, and treatment responses. However, the molecular basis for sex disparities in …

Regulation of sex hormone receptors in sexual dimorphism of human cancers

D Zheng, C Williams, JA Vold, JH Nguyen, DM Harnois… - Cancer letters, 2018 - Elsevier
Gender differences in the incidences of cancers have been found in almost all human
cancers. However, the mechanisms that underlie gender disparities in most human cancer …

Sexual inequality in the cancer cell

AP Arnold, CM Disteche - Cancer research, 2018 - AACR
Investigating sex differences in cancer will improve therapy for both sexes and discover sex-
specific protective mechanisms. Two recent analyses by Lopes-Ramos and colleagues and …

Sex differences in health and disease: A review of biological sex differences relevant to cancer with a spotlight on glioma

SC Massey, P Whitmire, TE Doyle, JE Ippolito… - Cancer letters, 2021 - Elsevier
The influence of biological sex differences on human health and disease, while being
increasingly recognized, has long been underappreciated and underexplored. While …