Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …

Gliomas are well known for their potential for aggressive proliferation as well as their diffuse
invasion of the normal-appearing parenchyma peripheral to the bulk lesion. This review …

Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

The invasion properties of glioblastoma hamper a radical surgery and are responsible for its
recurrence. Understanding the invasion mechanisms is thus critical to devise new …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

The current understanding of glioma biology reveals targets for anti-invasive therapy which
include manipulations of extracellular matrix and receptors, growth factors and cytokines …

Invasion of malignant glioma is a highly complex phenomenon involving molecular and
cellular processes at various spatio-temporal scales, whose precise interplay is still not fully …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Gliomas are brain tumours that differ from most other cancers by their diffuse invasion of the
surrounding normal tissue and their notorious recurrence following all forms of therapy. We …

The invasive capacity of GBM is one of the key tumoral features associated with treatment
resistance, recurrence, and poor overall survival. The molecular machinery underlying GBM …