Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder
Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy
known as the adder. This concept applies to various microbes and is often explained as the …
known as the adder. This concept applies to various microbes and is often explained as the …
A mechanistic stochastic framework for regulating bacterial cell division
How exponentially growing cells maintain size homeostasis is an important fundamental
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …
Determinants of cell size
M Björklund, S Marguerat - Frontiers in Cell and Developmental …, 2017 - frontiersin.org
Regulation of cell size has fascinated generations of biologists. While bacterial and
eukaryotic cells maintain a characteristic size (Lloyd, 2013; Wood and Nurse, 2015; Westfall …
eukaryotic cells maintain a characteristic size (Lloyd, 2013; Wood and Nurse, 2015; Westfall …
A Markovian approach towards bacterial size control and homeostasis in anomalous growth processes
Regardless of the progress achieved during recent years, the mechanisms coupling growth
and division to attain cell size homeostasis in bacterial populations are still not well …
and division to attain cell size homeostasis in bacterial populations are still not well …
Cell-size control and homeostasis in bacteria
How cells control their size and maintain size homeostasis is a fundamental open question.
Cell-size homeostasis has been discussed in the context of two major paradigms:" sizer," in …
Cell-size homeostasis has been discussed in the context of two major paradigms:" sizer," in …
Division in Escherichia coliis triggered by a size-sensing rather than a timing mechanism
L Robert, M Hoffmann, N Krell, S Aymerich, J Robert… - BMC biology, 2014 - Springer
Background Many organisms coordinate cell growth and division through size control
mechanisms: cells must reach a critical size to trigger a cell cycle event. Bacterial division is …
mechanisms: cells must reach a critical size to trigger a cell cycle event. Bacterial division is …
Inflating bacterial cells by increased protein synthesis
Understanding how the homeostasis of cellular size and composition is accomplished by
different organisms is an outstanding challenge in biology. For exponentially growing …
different organisms is an outstanding challenge in biology. For exponentially growing …
Exponential trajectories, cell size fluctuations, and the adder property in bacteria follow from simple chemical dynamics and division control
Experiments on steady-state bacterial cultures have uncovered several quantitative
regularities at the system level. These include, first, the exponential growth of cell size with …
regularities at the system level. These include, first, the exponential growth of cell size with …
Mechanistic origin of cell-size control and homeostasis in bacteria
Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …
homeostasis under steady-state conditions. In the presence of inherent physiological …
Details matter: noise and model structure set the relationship between cell size and cell cycle timing
Organisms across all domains of life regulate the size of their cells. However, the means by
which this is done is poorly understood. We study two abstracted “molecular” models for size …
which this is done is poorly understood. We study two abstracted “molecular” models for size …