Three-dimensional (3D) genomics is an emerging field of research that investigates the
relationship between gene regulatory function and the spatial structure of chromatin …

Each type of cell in the immune system performs critical functions to protect the body and
maintain health. In order to fulfil these roles some immune cells rely on unique processes …

Eukaryotic genomes are highly compacted in the cell nucleus. Two loci separated by a long
linear distance can be brought into proximity in space through DNA-binding proteins and …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

Abstract Three-dimensional (3D) genomics is an emerging discipline that studies the three-
dimensional structure of chromatin and the three-dimensional and functions of genomes. It …

The chromosomes in eukaryotic cells are highly folded and organized to form dynamic three-
dimensional (3D) structures. In recent years, many technologies including chromosome …

Recent sequence-based profiling technologies such as high-throughput sequencing to
detect fragment nucleotide sequence (Hi-C) and chromatin interaction analysis by paired …

Recent burst of new technologies that allow for quantitatively delineating chromatin structure
has greatly expanded our understanding of how the genome is organized in the three …

Since the advent of the chromosome conformation capture technology, our understanding of
the human genome 3D organization has grown rapidly and we now know that human …

Chromosomes located in the nucleus form discrete units of genetic material composed of
DNA and protein complexes. The genetic information is encoded in linear DNA sequences …