Mitochondrial determinants of doxorubicin-induced cardiomyopathy
KB Wallace, VA Sardão, PJ Oliveira - Circulation research, 2020 - Am Heart Assoc
Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
Mitochondria and doxorubicin-induced cardiomyopathy: a complex interplay
L Schirone, L D'Ambrosio, M Forte, R Genovese… - Cells, 2022 - mdpi.com
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …
nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer …
Doxorubicin‐induced cardiac mitochondrionopathy
KB Wallace - Pharmacology & toxicology, 2003 - Wiley Online Library
Doxorubicin (Adriamycin®) is a potent and broad‐spectrum antineoplastic agent prescribed
for the treatment of a variety of cancers, including both solid tumours and leukaemias …
for the treatment of a variety of cancers, including both solid tumours and leukaemias …
Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and
hematologic malignancies, but its clinical application is hampered by life-threatening …
hematologic malignancies, but its clinical application is hampered by life-threatening …
Effects of doxorubicin‐induced cardiotoxicity on cardiac mitochondrial dynamics and mitochondrial function: Insights for future interventions
N Osataphan, A Phrommintikul… - Journal of Cellular …, 2020 - Wiley Online Library
Anthracyclines is an effective chemotherapeutic treatment used for many types of cancer.
However, high cumulative dosage of anthracyclines leads to cardiac toxicity and heart …
However, high cumulative dosage of anthracyclines leads to cardiac toxicity and heart …
Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer‐targeted therapies
D Montaigne, C Hurt, R Neviere - Biochemistry research …, 2012 - Wiley Online Library
Anthracyclines remain the cornerstone of treatment in many malignancies but these agents
have a cumulative dose relationship with cardiotoxicity. Development of cardiomyopathy …
have a cumulative dose relationship with cardiotoxicity. Development of cardiomyopathy …
Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …
of cancer, but their clinical use is associated with severe and potentially life-threatening …
Mechanisms of anthracycline-induced cardiotoxicity: is mitochondrial dysfunction the answer?
A Murabito, E Hirsch, A Ghigo - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Cardiac side effects are a major drawback of anticancer therapies, often requiring the use of
low and less effective doses or even discontinuation of the drug. Among all the drugs known …
low and less effective doses or even discontinuation of the drug. Among all the drugs known …
Understanding anthracycline cardiotoxicity from mitochondrial aspect
J Huang, R Wu, L Chen, Z Yang, D Yan… - Frontiers in …, 2022 - frontiersin.org
Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …
Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration
Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular
dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive …
dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive …