Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization
in US infants, but also a major risk factor for asthma development. While emerging evidence …

Background Young children with rhinovirus (RV) infection—particularly bronchiolitis—are at
high risk for developing childhood asthma. Emerging evidence suggests clinical …

Background Severe bronchiolitis (ie, bronchiolitis requiring hospitalization) during infancy is
a major risk factor for childhood asthma. However, the exact mechanism linking these …

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections and
hospital visits during infancy and childhood. Although risk factors for RSV infection have …

Relatively little is known about interactions between the airway microbiome and airway host
transcriptome in asthma. Since asthma affects and is affected by the entire airway, studying …

Background Pediatric asthma is the most common chronic childhood disease in the USA,
currently affecting~ 7 million children. This heterogeneous syndrome is thought to …

Rationale: Bronchiolitis is the most common lower respiratory infection in infants; however, it
remains unclear which infants with bronchiolitis will develop severe illness. In addition …

Background High-throughput sequencing (HTS) analysis of microbial communities from the
respiratory airways has heavily relied on the 16S rRNA gene. Given the intrinsic limitations …

Early-life acute respiratory infection (ARI) with respiratory syncytial virus (RSV) has been
strongly associated with the development of childhood asthma (1), but the pathways …

Background Early interactions between respiratory viruses and microbiota might modulate
host immune responses and subsequently contribute to later development of recurrent …