Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

Adjustments of respiration and circulation in response to alterations in the levels of oxygen,
carbon dioxide and hydrogen ions in the body fluids are mediated by two distinct …

Central chemoreceptors appear to be widely distributed in the brainstem. Why are there so
many central chemoreceptor sites? This review focuses on two hypotheses.(1) The high …

Much progress has been made in our understanding of central chemoreception since the
seminal experiments of Fencl, Loeschcke, Mitchell and others, including identification of new …

Central chemoreception is the mechanism by which arterial blood PCO2 is detected by the
CNS to regulate breathing. Two main theories have been proposed to account for the …

By definition central respiratory chemoreceptors (CRCs) are cells that are sensitive to
changes in brain PCO2 or pH and contribute to the stimulation of breathing elicited by …

To some it may seem that we now know less about respiratory chemoreception than we did
20 years ago. Back then, it was widely accepted that the central respiratory chemoreceptors …

In this review we discuss the implications for ventilatory control of newer evidence
suggesting that central and peripheral chemoreceptors are not functionally separate but …

CENTRAL CHEMORECEPTION refers to detection of CO2/pH within the brain and the
subsequent reflex effects on breathing. It involves multiple sites within the hindbrain (9, 12 …

When all peripheral chemoreceptors are denervated, animals continue to show increased
ventilation when made to breathe CO2, indicating that receptors within the brain (“central …