Tumor necrosis factor α (TNF-α) binding to the TNF receptor (TNFR) potentially initiates
apoptosis and activates the transcription factor nuclear factor kappa B (NF-κB), which …

Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including
activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous …

Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)-associated signal
transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated …

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved
are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF …

We have recently shown that stimulation of TNF-R2 selectively enhances apoptosis
induction by the death receptor TNF-R1. Here, we demonstrate that stimulation of CD30 or …

TRAF2 is an intracellular signal-transducing protein recruited to the TNFR1 and TNFR2
receptors following TNF stimulation. To investigate the physiological role of TRAF2, we …

Tumour necrosis factor-α (TNF-α) is a proinflammatory mediator that exerts its biological
functions by binding two TNF receptors (TNF-RI and TNF-RII), which initiate biological …

Tumor necrosis factor (TNF) family members are essential for the development and proper
functioning of the immune system. TNF receptor (TNFR) signaling is mediated through the …

TNF receptor-associated factor (TRAF) proteins are candidate signal transducers that
associate with the cytoplasmic domains of members of the tumor necrosis factor (TNF) …

The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively …