Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The initial phases of embryonic development occur in the absence of de novo transcription
and are instead controlled by maternally inherited mRNAs and proteins. During this initial …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The shift from maternal to embryonic control is a critical developmental milestone in
preimplantation development. Widespread transcriptomic and epigenetic remodeling …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Cellular transitions occur at all stages of organismal life from conception to adult
regeneration. Changing cellular state involves three main features: activating gene …

The hiatus between oocyte and embryonic gene transcription dictates a role for stored
maternal factors in early mammalian development. Encoded by maternal-effect genes, these …

All animal embryos pass through a stage during which developmental control is handed
from maternally provided gene products to those synthesized from the zygotic genome. This …