Physiological limitations and opportunities in microbial metabolic engineering

J Montaño López, L Duran, JL Avalos - Nature Reviews Microbiology, 2022 - nature.com
Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Prospects of microbial cell factories developed through systems metabolic engineering

M Gustavsson, SY Lee - Microbial Biotechnology, 2016 - Wiley Online Library
While academic‐level studies on metabolic engineering of microorganisms for production of
chemicals and fuels are ever growing, a significantly lower number of such production …

Importance of systems biology in engineering microbes for biofuel production

A Mukhopadhyay, AM Redding, BJ Rutherford… - Current opinion in …, 2008 - Elsevier
Microorganisms have been rich sources for natural products, some of which have found use
as fuels, commodity chemicals, specialty chemicals, polymers, and drugs, to name a few …

Recent trends in metabolic engineering of microbial chemical factories

Y Liu, J Nielsen - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Microbial cell factories can be tailored for producing certain 'drop-in'chemicals.•
Metabolic engineering has greatly enhanced the development of microbial cell …

Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering

KR Choi, WD Jang, D Yang, JS Cho, D Park… - Trends in …, 2019 - cell.com
Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Construction and optimization of synthetic pathways in metabolic engineering

D Na, TY Kim, SY Lee - Current opinion in microbiology, 2010 - Elsevier
Metabolic engineering has enabled us to develop strains suitable for their use as microbial
factories of chemicals and materials from renewable sources. It has recently become more …

[HTML][HTML] Advances in the development and application of microbial consortia for metabolic engineering

K Jawed, SS Yazdani, MAG Koffas - Metabolic engineering …, 2019 - Elsevier
Recent advances in metabolic engineering enable the production of high-value chemicals
via expressing complex biosynthetic pathways in a single microbial host. However, many …

The importance of engineering physiological functionality into microbes

Y Zhang, Y Zhu, Y Zhu, Y Li - Trends in Biotechnology, 2009 - cell.com
Good physiological performance of industrial microbes is crucial for successful
bioprocesses. Conventional metabolism-oriented engineering strategies often fail to obtain …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …