There are several routes of administration to the brain, including intraparenchymal,
intraventricular, and subarachnoid injections. The blood-brain barrier (BBB) impedes the …

The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

Although the global prevalence of neurological disorders such as Parkinson's disease,
Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing …

Treating diseases of the central nervous system (CNS) still remains a problem for the
researchers. Existence of specific anatomical barriers, especially the blood brain barrier …

The brain is the most delicate, complex, and vital organ of the human body, and is highly
protected by different protective structures including skull, meninges, cerebrospinal fluid …

The blood-brain barrier (BBB) has a very significant role in drug delivery to the brain, which
allows passes of only a few molecules. Conventional drug delivery systems have very …

Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …

Alzheimer's disease (AD) is one of the neurological ailments which continue to represent a
major public health challenge, owing to increased life expectancy and aging population …

The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is
generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs …

The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …