Cognitive impairment has been associated with an age-related decline in adult hippocampal
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …

Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the
extracellular matrix, which has recently starting to attract attention as a significant …

Pleiotrophin (PTN) is a growth factor that has been shown to be involved in hippocampal
synaptic plasticity and learning. To further understand the involvement of PTN in memory …

Pleiotrophin (PTN) is an effective neuroprotective factor and its expression is strikingly
increased in microglia after ischemia/reperfusion injury. However, whether PTN could …

Background Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in
different disorders characterized by overt neuroinflammation such as neurodegenerative …

Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and
neuroprotective effects that is involved in a variety of neurodevelopmental processes. Data …

Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central
nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated …

To understand what kind of trophic factors are up‐regulated in dopamine (DA)‐depleted
striatum, we first analysed the up‐regulation of mRNAs using a DNA microarray in DA …

Heparin-binding growth-associated molecule (HB-GAM)(pleiotrophin) is a highly conserved
extracellular matrix-associated protein implicated in a diverse range of developmental …

Pleiotrophin (PTN) is highly expressed in the nervous system during embryogenesis;
however, little is known about its functional role in neural development. By using whole …