Cancer is one of the major causes of death and a significant obstacle to increasing life
expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for …

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis
and in mediating chemotherapy sensitivity and resistance. Recent research shows that the …

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,
progression, and drug resistance. Recent research shows that FOXM1 is a direct …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …

Many advanced cancers receive cisplatin‐based chemotherapy. However, cisplatin
resistance is a major obstacle for cancer chemotherapy. Foxo3a is a member of the Foxo …

FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

FOXO3a and FOXM1 are two forkhead transcription factors with antagonistic roles in cancer
and DNA damage response. FOXO3a functions like a typical tumour suppressor, whereas …

Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …