Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous
adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine …

Adenosine is known to regulate myocardial and coronary circulatory functions. Adenosine
not only dilates coronary vessels, but attenuates beta-adrenergic receptor-mediated …

Adenosine is an autacoid that plays a critical role in regulating cardiac function, including
heart rate, contractility, and coronary flow. In this chapter, current knowledge of the functions …

The purine nucleoside adenosine is an important regulator within the cardiovascular system,
and throughout the body. Released in response to perturbations in energy state, among …

Adenosine is widely distributed in mammals. One of the primary roles of adenosine within
the cardiovascular system is to directly control the functions of both cardiac and vascular …

Adenosine receptors may be divided into two subtypes termed A1 and A2 which inhibit or
stimulate, respectively, the enzyme adenylate cyclase. Adenosine is capable of regulating …

FOUR SUBTYPES OF ADENOSINE RECEPTORS (A1, A2A, A2B, and A3 receptors) are
known to exist (26). Traditionally, the A1-adenosine receptor has been thought to be the only …

The results, briefly summarized above, indicate that adenosine could be a physiologically
important modulator of several aspects of cardiovascular regulation. Most cells are equipped …

Adenosine modulates a variety of physiological functions through interaction with A1 and A2
adenosine receptors, where agonists mediate inhibition and stimulation, respectively, of …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …