T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Naive CD4+ T lymphocytes differentiate into various Th cell subsets following TCR binding
to microbial peptide: MHC class II (p: MHCII) complexes on dendritic cells (DCs). The affinity …

While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it
is less clear why a dichotomy of effector cytokine production would initiate from antigen …

The strength of interactions between T cell receptors and the peptide-major
histocompatibility complex (pMHC) directly modulates T cell fitness, clonal expansion, and …

T cell development, differentiation, and maintenance are orchestrated by 2 key signaling
axes: the antigen-specific TCR and cytokine-mediated signals. The TCR signals the …

The ability of CD4+ T cells to differentiate into effector subsets underpins their ability to
shape the immune response and mediate host protection. During T cell receptor-induced …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Over the last two decades the molecular and cellular mechanisms underlying T cell
activation, expansion, differentiation, and memory formation have been intensively …

In the periphery, upon antigen recognition by αβTCR, naïve CD4 T cells undergo functional
differentiation and acquire the ability to produce a specific set of cytokines. At least four Th …

CD8 engagement is believed to be a critical event in the activation of naive T cells. In this
communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the …