Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM)
and normal cells, in particular tumour-associated macrophages (TAM). To understand the …

In human breast cancer (HBC), as with many carcinoma systems, most matrix
metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour …

Cancer cells evolve in the tumor microenvironment (TME) by the acquisition of
characteristics that allow them to initiate their passage through a series of events that …

Several matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) were
studied in highly invasive (MDA-MB-231) and slightly invasive (MCF-7, T47D, BT-20) breast …

The inflammatory milieu plays an important role in colon cancer development and
progression. Previously, we have shown that tumor‐associated macrophages (TAMs), an …

Abstract MT1-MMP (membrane type-1 matrix metalloproteinase), otherwise known as
MMP14 is a proteolytic enzyme known to be involved in degradating extracellular matrix and …

Functional roles for the cancer cell–associated membrane type I matrix metalloproteinase
(MT1-MMP) during early steps of the metastatic cascade in primary tumors remain …

Co-culture of periodontal ligament (PDL) fibroblasts and SCC-25 oral squamous carcinoma
cells (OSCC), results in conversion of PDLs into carcinoma-associated fibroblasts (CAFs) …

Activation of pro-matrix metalloproteinase (MMP)-2 on the surface of malignant cells by
membrane-bound MT1-MMP is believed to play a critical role during tumor progression and …

Tumor-associated macrophages are known to amplify the malignant potential of tumors by
secreting a variety of cytokines and proteases involved in tumor cell invasion and …