Membrane fusion in cells: molecular machinery and mechanisms

M Leabu - Journal of cellular and molecular medicine, 2006 - Wiley Online Library
Membrane fusion is a sine qua non process for cell physiology. It is critical for membrane
biogenesis, intracellular traffic, and cell secretion. Although investigated for over a century …

Role of SNAREs in membrane fusion

BP Jena - Cell Fusion in Health and Disease, 2011 - Springer
Fusion between opposing cellular membranes is essential for numerous cellular activities
such as protein maturation, neurotransmission, hormone secretion, and enzyme release …

Testing the SNARE/SM protein model of membrane fusion

T Bacaj, ZP Pang, TC Südhof - Proceedings of the National …, 2010 - National Acad Sciences
In eukaryotic cells, the budding and fusion of membranes mediates diverse but essential
processes, ranging from cell division to organelle biogenesis to neurotransmitter secretion …

What is the role of SNARE proteins in membrane fusion?

JG Duman, JG Forte - American Journal of Physiology-Cell …, 2003 - journals.physiology.org
Soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) proteins have
been at the fore-front of research on biological membrane fusion for some time. The …

SNAREpins are functionally resistant to disruption by NSF and αSNAP

T Weber, F Parlati, JA McNew, RJ Johnston… - The Journal of cell …, 2000 - rupress.org
SNARE (SNAP [soluble NSF {N-ethylmaleimide–sensitive fusion protein} attachment
protein] receptor) proteins are required for many fusion processes, and recent studies of …

Membrane fusion: role of SNAREs and calcium

BP Jena - Protein and peptide letters, 2009 - ingentaconnect.com
Life processes are governed at the chemical level, and therefore knowledge of how single
molecules interact, provides a fundamental understanding of nature. The molecular …

[HTML][HTML] Intracellular vesicle fusion requires a membrane-destabilizing peptide located at the juxtamembrane region of the v-SNARE

SS Rathore, Y Liu, H Yu, C Wan, MS Lee, Q Yin… - Cell reports, 2019 - cell.com
Intracellular vesicle fusion is mediated by soluble N-ethylmaleimide sensitive factor
attachment protein receptors (SNAREs) and Sec1/Munc18 (SM) proteins. It is generally …

[HTML][HTML] The multifaceted role of SNARE proteins in membrane fusion

J Han, K Pluhackova, RA Böckmann - Frontiers in physiology, 2017 - frontiersin.org
Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …

Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors

JA McNew, T Weber, F Parlati, RJ Johnston… - The Journal of cell …, 2000 - rupress.org
Is membrane fusion an essentially passive or an active process? It could be that fusion
proteins simply need to pin two bilayers together long enough, and the bilayers could do the …

SNARE-catalyzed fusion events are regulated by Syntaxin1A–lipid interactions

AD Lam, P Tryoen-Toth, B Tsai, N Vitale… - Molecular biology of …, 2008 - Am Soc Cell Biol
Membrane fusion is a process that intimately involves both proteins and lipids. Although the
SNARE proteins, which ultimately overcome the energy barrier for fusion, have been …