The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation
of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to …

Background: β-thalassemia causes a severe hemolytic anemia in patients necessitating
frequent transfusions lead-ing to iron overload and endocrine complications, especially …

Background: In beta-thalassemia major impaired biosynthesis of beta globin leads to
accumulation of unpaired alpha globin chain. An iron overload, usually observed, generates …

Blood transfusion can be a life-saving therapy for β-thalassemia major and β-
thalassemia/HbE (β-TM) patients with chronic anemia, major caused severe iron overload …

Background Serum lipids and glycemic dysregulation are the known characteristics of β-
thalassemia major (β-TM). Here, we evaluated the association of these disorders with insulin …

In beta thalassemia, decreased or impaired biosynthesis of β-globin leads to accumulation
of unpaired α-globin chains. Excess presence of the α-globin in chains is the primary reason …

Because of continuous blood transfusions, thalassemia patients are subjected to
peroxidative tissue injury by the secondary iron overload. In accordance, analysis of serum …

Background: Homozygous β thalassemia may lead to a marked reduction or absence of
normal β chain production and accumulation of unpaired alpha-globin chains. A crucial …

A study on thalassemia intermedia and major patients in Jakarta was initiated to obtain a
comprehensive picture of metabolic dysregulation, iron overload, oxidative stress, and cell …

Malonaldehyde (MDA), a biomarker of oxidative stress is found to be increased in many
individuals suffering from β-thalassemia. This may possibly be attributed to iron overload …