Even after decades of research, the mechanism of neurodegeneration remains
understudied, hindering the discovery of effective treatments for neurodegenerative …

Ferroptosis, an iron-dependent regulated cell death triggered by high lipid peroxide levels,
has been implicated in several neurodegenerative diseases, including Parkinson's disease …

Apoptosis, necroptosis, autophagy, and ferroptosis are distinct mechanisms of cell death. In
this issue of Cell Chemical Biology, Magtanong et al.(2019) demonstrated that exogenous …

Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …

Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA 1 s) are
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …

Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

Simple Summary Ferroptosis is a type of cell death, which is morphologically and
mechanistically distinct from other type of cell death pathways such as apoptosis and …

Enigmatic lipid peroxidation products have been claimed as the proximate executioners of
ferroptosis—a specialized death program triggered by insufficiency of glutathione …

Polyunsaturated ether phospholipids, previously thought to oppose propagation of lipid
peroxidation, have been reported to promote the cells' susceptibility to ferroptotic cell death …

The central mechanism in ferroptosis linking lipid hydroperoxide accumulation with cell
death remains poorly understood. Although lipid hydroperoxides are known to break down …