Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain
Known human immunodeficiency virus (HIV) transmission histories are invaluable models
for investigating the evolutionary and transmission dynamics of the virus and to assess the …
for investigating the evolutionary and transmission dynamics of the virus and to assess the …
Identification of drug resistance mutations in HIV from constraints on natural evolution
Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its
evolution is constrained by interactions between mutations in its fitness landscape. Here we …
evolution is constrained by interactions between mutations in its fitness landscape. Here we …
HIV-1 pol gene variation is sufficient for reconstruction of transmissions in the era of antiretroviral therapy
Objectives: We wished to assess the potential of using HIV-1 pol gene for the identification of
transmissions events by phylogenetic means in the era of antiretroviral drug selective …
transmissions events by phylogenetic means in the era of antiretroviral drug selective …
[HTML][HTML] Quantifying the fitness cost of HIV-1 drug resistance mutations through phylodynamics
Drug resistant HIV is a major threat to the long-term efficacy of antiretroviral treatment.
Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1 …
Around 10% of ART-naïve patients in Europe are infected with drug-resistant HIV type 1 …
Inference of epistatic effects leading to entrenchment and drug resistance in HIV-1 protease
Understanding the complex mutation patterns that give rise to drug resistant viral strains
provides a foundation for developing more effective treatment strategies for HIV/AIDS …
provides a foundation for developing more effective treatment strategies for HIV/AIDS …
Estimating selection pressures on HIV‐1 using phylogenetic likelihood models
Abstract Human immunodeficiency virus (HIV‐1) can rapidly evolve due to selection
pressures exerted by HIV‐specific immune responses, antiviral agents, and to allow the …
pressures exerted by HIV‐specific immune responses, antiviral agents, and to allow the …
[HTML][HTML] Inferring HIV transmission dynamics from phylogenetic sequence relationships
Inferring HIV Transmission Dynamics from Phylogenetic Sequence Relationships | PLOS
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[HTML][HTML] Loss and recovery of genetic diversity in adapting populations of HIV
PS Pennings, S Kryazhimskiy, J Wakeley - PLoS genetics, 2014 - journals.plos.org
The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-
resistance mutations, but the underlying population genetic processes are not well …
resistance mutations, but the underlying population genetic processes are not well …
[HTML][HTML] Standing genetic variation and the evolution of drug resistance in HIV
PS Pennings - PLoS computational biology, 2012 - journals.plos.org
Drug resistance remains a major problem for the treatment of HIV. Resistance can occur due
to mutations that were present before treatment starts or due to mutations that occur during …
to mutations that were present before treatment starts or due to mutations that occur during …
Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naive individuals
S Hué, RJ Gifford, D Dunn, E Fernhill… - Journal of virology, 2009 - Am Soc Microbiol
Transmission of human immunodeficiency virus (HIV) drug resistance is well-recognized
and compromises response to first-line therapy. However, the population dynamics of …
and compromises response to first-line therapy. However, the population dynamics of …