A nuclear mRNA degradation (DRN) system was identified from analysis of mRNA turnover
rates in nup116-Δ strains of Saccharomyces cerevisiae lacking the ability to export all RNAs …

We previously demonstrated an increased degradation of mRNAs in mutants of
Saccharomyces cerevisiae having blocks in nuclear export. The degradation activity …

The cyc1-512 mutation in Saccharomyces cerevisiae causes a 90% reduction in the level of
iso-1-cytochrome c because of the lack of a proper 3′-end-forming signal, resulting in low …

Nucleocytoplasmic transport of mRNA is essential for eukaryotic gene expression. However,
how mRNA is exported from the nucleus is mostly unknown. To elucidate the mechanisms of …

In the yeast Saccharomyces cerevisiae, a common conditional phenotype associated with
deletion or mutation of genes encoding mRNA export factors is the rapid accumulation of …

To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …

ABSTRACT mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a
pathway that is stimulated by removal of the mRNA cap structure. Here we report that a …

Eukaryotes produce a number of noncoding transcripts from intergenic regions. In
Saccharomyces cerevisiae, such cryptic unstable transcripts (CUTs) are thought to be …

We have identified a nuclear pathway that rapidly degrades unspliced pre-mRNAs in yeast.
This involves 3′→ 5′ degradation by the exosome complex and 5′→ 3′ degradation by …

Inactivation of poly (A) polymerase (encoded by PAP1) in Saccharomyces cerevisiae cells
carrying the temperature-sensitive, lethal pap1-1 mutation results in reduced levels of poly …