Cytokine adjuvants IL-7 and IL-15 improve humoral responses of a SHIV LentiDNA vaccine in animal models
HIV-1 remains a major public health issue worldwide in spite of efficacious antiviral
therapies, but with no cure or preventive vaccine. The latter has been very challenging, as …
therapies, but with no cure or preventive vaccine. The latter has been very challenging, as …
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques
Intramuscular injection of macaques with an IL-12 expression plasmid (0.1 or 0.4 mg
DNA/animal) optimized for high level of expression and delivered using in vivo …
DNA/animal) optimized for high level of expression and delivered using in vivo …
[HTML][HTML] Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers …
RA Dubie, S Maksaereekul, BL Shacklett… - Virology, 2009 - Elsevier
Simian immunodeficiency virus (SIV) infection of rhesus macaques is a valuable animal
model for human immunodeficiency virus (HIV)-1 vaccine development. Our laboratory …
model for human immunodeficiency virus (HIV)-1 vaccine development. Our laboratory …
Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques
AS Beignon, K Mollier, C Liard, F Coutant… - Journal of …, 2009 - Am Soc Microbiol
ABSTRACT AIDS vaccination has a pressing need for more potent vaccination vectors
capable of eliciting strong, diversified, and long-lasting cellular immune responses against …
capable of eliciting strong, diversified, and long-lasting cellular immune responses against …
Protection from immunodeficiency virus challenges in rhesus macaques by multicomponent DNA immunization
Multicomponent DNA vaccines were used to elicit immune responses, which can impact
viral challenge in three separate rhesus macaque models. Eight rhesus macaques were …
viral challenge in three separate rhesus macaque models. Eight rhesus macaques were …
A single lentivector DNA based immunization contains a late heterologous SIVmac251 mucosal challenge infection
Y Chebloune, M Moussa, G Arrode-Brusés, C Ronfort… - Vaccine, 2020 - Elsevier
Variety of conventional vaccine strategies tested against HIV-1 have failed to induce
protection against HIV acquisition or durable control of viremia. Therefore, innovative …
protection against HIV acquisition or durable control of viremia. Therefore, innovative …
A therapeutic SIV DNA vaccine elicits T-cell immune responses, but no sustained control of viremia in SIVmac239-infected rhesus macaques
J zur Megede, B Sanders-Beer, P Silvera… - AIDS research and …, 2008 - liebertpub.com
The immunologic and virologic outcome of therapeutic DNA-vaccines administered during
antiretroviral therapy (ART) using electroporation with or without (interleukin) IL-2 treatment …
antiretroviral therapy (ART) using electroporation with or without (interleukin) IL-2 treatment …
Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques
J Yan, DA Hokey, MP Morrow, N Corbitt, K Harris… - Vaccine, 2009 - Elsevier
Cellular immunity plays an important role in controlling HIV-1 replication. One of the major
challenges in developing an HIV-1 DNA vaccine is to generate broader and more potent …
challenges in developing an HIV-1 DNA vaccine is to generate broader and more potent …
Long-term central and effector SHIV-specific memory T cell responses elicited after a single immunization with a novel lentivector DNA vaccine
G Arrode-Bruses, M Moussa, M Baccard-Longere… - PloS one, 2014 - journals.plos.org
Prevention of HIV acquisition and replication requires long lasting and effective immunity.
Given the state of HIV vaccine development, innovative vectors and immunization strategies …
Given the state of HIV vaccine development, innovative vectors and immunization strategies …
Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease …
SY Chong, MA Egan, MA Kutzler, S Megati, A Masood… - Vaccine, 2007 - Elsevier
Plasmid-based IL-12 has been demonstrated to successfully enhance the immunogenicity of
DNA vaccines, thus enabling a reduction of the amount of DNA required for immunization. IL …
DNA vaccines, thus enabling a reduction of the amount of DNA required for immunization. IL …