Is lipid signaling through cannabinoid 2 receptors part of a protective system?

P Pacher, R Mechoulam - Progress in lipid research, 2011 - Elsevier
The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …

The emerging role of the endocannabinoid system in cardiovascular disease

P Pacher, S Steffens - Seminars in immunopathology, 2009 - Springer
Endocannabinoids are endogenous bioactive lipid mediators present both in the brain and
various peripheral tissues, which exert their biological effects via interaction with specific G …

Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …

D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Endocannabinoids and immune regulation

R Pandey, K Mousawy, M Nagarkatti… - Pharmacological …, 2009 - Elsevier
Cannabinoid pharmacology has made important advances in recent years after the
discovery of the cannabinoid receptors. These discoveries have added to our understanding …

Modulating the endocannabinoid system in human health and disease–successes and failures

P Pacher, G Kunos - The FEBS journal, 2013 - Wiley Online Library
The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Antiinflammatory cannabinoids in diet – towards a better understanding of CB2 receptor action? Towards a better understanding of CB2 receptor action?

J Gertsch - Communicative & integrative biology, 2008 - Taylor & Francis
The endocannabinoid system is an ancient lipid signalling network which in mammals
modulates neuronal functions, inflammatory processes, and is involved in the aetiology of …

Endocannabinoids and the immune system in health and disease

GA Cabral, GA Ferreira, MJ Jamerson - Endocannabinoids, 2015 - Springer
Endocannabinoids are bioactive lipids that have the potential to signal through cannabinoid
receptors to modulate the functional activities of a variety of immune cells. Their activation of …

Stress regulates endocannabinoid-CB1 receptor signaling

CJ Hillard - Seminars in immunology, 2014 - Elsevier
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed
throughout the brain. The endogenous ligands for the CB1 receptor (endocannabinoids) are …

Targeting cannabinoid receptor CB2 in cardiovascular disorders: promises and controversies

S Steffens, P Pacher - British journal of pharmacology, 2012 - Wiley Online Library
Cardiovascular disease is the leading cause of death and disability worldwide, which can be
largely attributed to atherosclerosis, a chronic inflammation of the arteries characterized by …

The therapeutic potential of novel cannabinoid receptors

FR Kreitzer, N Stella - Pharmacology & therapeutics, 2009 - Elsevier
Cannabinoids produce a plethora of biological effects, including the modulation of neuronal
activity through the activation of CB1 receptors and of immune responses through the …