Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies

B Evranos-Aksöz, S Yabanoğlu-Çiftçi, G Uçar… - Bioorganic & medicinal …, 2014 - Elsevier
A novel series of 2-pyrazoline and hydrazone derivatives were synthesized and investigated
for their human monoamine oxidase (hMAO) inhibitory activity. All compounds inhibited the …

Synthesis and screening of human monoamine oxidase‐A inhibitor effect of new 2‐pyrazoline and hydrazone derivatives

B Evranos‐Aksöz, İ Baysal… - Archiv der …, 2015 - Wiley Online Library
A group of 3, 5‐diaryl‐2‐pyrazoline and hydrazone derivatives was prepared via the
reaction of various chalcones with hydrazide compounds in ethanol. Twenty original …

New 2-pyrazoline and hydrazone derivatives as potent and selective monoamine oxidase A inhibitors

U Salgin-Goksen, G Telli, A Erikci… - Journal of medicinal …, 2021 - ACS Publications
Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3, 5-
disubstitutedphenyl-2-pyrazoline structure and nine compounds having N′-(1, 3 …

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors

G Turan-Zitouni, W Hussein, BN Sağlık, A Tabbi… - Molecules, 2018 - mdpi.com
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and
efficient method. The final compounds obtained were screened for their inhibitory potency …

Synthesis of new hydrazone derivatives and evaluation of their monoamine oxidase inhibitory activity

F Tok, BN Sağlık, Y Özkay, S Ilgın, ZA Kaplancıklı… - Bioorganic …, 2021 - Elsevier
A novel series of hydrazone derivatives were designed and synthesized. Their structures
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …

Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies

A Sahoo, S Yabanoglu, BN Sinha, G Ucar… - Bioorganic & medicinal …, 2010 - Elsevier
Ten novel 3, 5-diaryl pyrazolines were synthesized and investigated for their monoamine
oxidase (MAO) inhibitory property. All the molecules were found to be reversible and …

Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors

MD Altintop, B Sever, D Osmaniye… - Archiv der …, 2018 - Wiley Online Library
In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives
were obtained via the selective reduction of the C C bonds of 1‐(1‐methyl‐1H‐pyrrol‐2‐yl) …

Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives

F Chimenti, E Maccioni, D Secci… - Journal of medicinal …, 2007 - ACS Publications
A series of 2-thiazolylhydrazone derivatives have been investigated for the ability to inhibit
the activity of the A and B isoforms of monoamine oxidase (MAO) selectively. All of the …

(Thiazol-2-yl) hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

M D'Ascenzio, P Chimenti, MC Gidaro… - Journal of Enzyme …, 2015 - Taylor & Francis
Abstract Several (thiazol-2-yl) hydrazone derivatives from 2-, 3-and 4-acetylpyridine were
synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most …

Monoamine oxidase inhibitory activity of novel pyrazoline analogues: Curcumin based design and synthesis

VN Badavath, I Baysal, G Ucar, BN Sinha… - ACS Medicinal …, 2016 - ACS Publications
A series of new 2-methoxy-4-(5-phenyl-4, 5-dihydro-1 H-pyrazol-3-yl) phenolderivatives, 4–
13, were synthesized and tested for their human MAO inhibitory activity. All the compounds …