Next-generation derivatization reagents optimized for enhanced product ion formation in photodissociation-mass spectrometry of fatty acids

VR Narreddula, BI McKinnon, SJP Marlton… - Analyst, 2021 - pubs.rsc.org
Ultraviolet-photodissociation (UVPD) mass spectrometry is an emerging analytical tool for
structural elucidation of biomolecules including lipids. Gas phase UVPD of ionised fatty …

Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives

HT Pham, AJ Trevitt, TW Mitchell… - … in Mass Spectrometry, 2013 - Wiley Online Library
RATIONALE Both traditional electron ionization and electrospray ionization tandem mass
spectrometry have demonstrated limitations in the unambiguous identification of fatty acids …

Introduction of a fixed-charge, photolabile derivative for enhanced structural elucidation of fatty acids

VR Narreddula, NR Boase, R Ailuri… - Analytical …, 2019 - ACS Publications
Fatty acids are a structurally diverse category of lipids with a myriad of biochemical
functions, which includes their role as building blocks of more complex lipids (eg …

Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives

VR Narreddula, P Sadowski… - Rapid …, 2020 - Wiley Online Library
Rationale Eicosanoids are short‐lived bio‐responsive lipids produced locally from oxidation
of polyunsaturated fatty acids (FAs) via a cascade of enzymatic or free radical reactions …

[HTML][HTML] Site-specific photochemical reaction for improved C= C location analysis of unsaturated lipids by ultraviolet photodissociation

HF Li, J Zhao, W Cao, W Zhang, Y Xia, Z Ouyang - Research, 2022 - spj.science.org
Unraveling the complexity of the lipidome requires the development of novel approaches to
facilitate structural identification and characterization of lipid species with isomer-level …

Evaluation of ultraviolet photodissociation tandem mass spectrometry for the structural assignment of unsaturated fatty acid double bond positional isomers

M Fang, Y Rustam, M Palmieri, OM Sieber… - Analytical and …, 2020 - Springer
Fatty acids are a major source of structural diversity within the lipidome due to variations in
their acyl chain lengths, branching, and cyclization, as well as the number, position, and …

IR and UV photodissociation as analytical tools for characterizing lipid A structures

JA Madsen, TW Cullen, MS Trent… - Analytical chemistry, 2011 - ACS Publications
The utility of 193-nm ultraviolet photodissociation (UVPD) and 10.6-μm infrared multiphoton
dissociation (IRMPD) for the characterization of lipid A structures was assessed in an ion …

Double bond characterization of free fatty acids directly from biological tissues by ultraviolet photodissociation

CL Feider, LA Macias, JS Brodbelt… - Analytical …, 2020 - ACS Publications
Free fatty acids (FA) are a vital component of cells and are critical to cellular structure and
function, so much so that alterations in FA are often associated with cell malfunction and …

Enhancing the signal-to-noise of diagnostic fragment ions of unsaturated glycerophospholipids via precursor exclusion ultraviolet photodissociation mass …

SWJ Shields, JD Sanders, JS Brodbelt - Analytical chemistry, 2022 - ACS Publications
Understanding and elucidating the diverse structures and functions of lipids has motivated
the development of many innovative tandem mass spectrometry (MS/MS) strategies. Higher …

Ultraviolet photodissociation mass spectrometry for analysis of biological molecules

JS Brodbelt, LJ Morrison, I Santos - Chemical reviews, 2019 - ACS Publications
The development of new ion-activation/dissociation methods continues to be one of the most
active areas of mass spectrometry owing to the broad applications of tandem mass …