Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
Studies of the role of actin in tumour progression have highlighted its key contribution in cell
softening associated with cell invasion. Here, using a human breast cell line with conditional …
softening associated with cell invasion. Here, using a human breast cell line with conditional …
Effect of actin organization on the stiffness of living breast cancer cells revealed by peak-force modulation atomic force microscopy
We study the correlation between cytoskeleton organization and stiffness of three epithelial
breast cancer cells lines with different degrees of malignancy: MCF-10A (healthy), MCF-7 …
breast cancer cells lines with different degrees of malignancy: MCF-10A (healthy), MCF-7 …
Effects of energy metabolism on the mechanical properties of breast cancer cells
Tumorigenesis induces actin cortex remodeling, which makes cancerous cells softer. Cell
deformability is largely determined by myosin-driven cortical tension and actin fiber …
deformability is largely determined by myosin-driven cortical tension and actin fiber …
Actin filaments play a primary role for structural integrity and viscoelastic response in cells
AN Ketene, PC Roberts, AA Shea… - Integrative …, 2012 - academic.oup.com
This atomic force microscopy (AFM) study is devoted to the analysis of the mouse ovarian
cancer cell's cytoskeleton components and the impact of both actin and microtubulin …
cancer cell's cytoskeleton components and the impact of both actin and microtubulin …
Mechanical compression drives cancer cells toward invasive phenotype
JM Tse, G Cheng, JA Tyrrell… - Proceedings of the …, 2012 - National Acad Sciences
Uncontrolled growth in a confined space generates mechanical compressive stress within
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Increased tissue stiffness is a classic characteristic of solid tumors. One of the major
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …
[PDF][PDF] Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential
While significant advances have been made toward revealing the molecular mechanisms
that influence breast cancer progression, much less is known about the associated cellular …
that influence breast cancer progression, much less is known about the associated cellular …
Invasive cancer cell lines exhibit biomechanical properties that are distinct from their noninvasive counterparts
Identifying the properties that distinguish invasive cells from noninvasive cells is of prime
interest in understanding metastasis formation during cancer. We have taken pairs of cells …
interest in understanding metastasis formation during cancer. We have taken pairs of cells …
Tissue force programs cell fate and tumor aggression
JJ Northey, L Przybyla, VM Weaver - Cancer discovery, 2017 - AACR
Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue …
direct cell fate during development and are critical for the maintenance of tissue …
Correlating the viscoelasticity of breast cancer cells with their malignancy
Initiation and development of cancer are usually accompanied by alterations in the cellular
mechanical properties such as its stiffness and viscosity. Understanding the viscoelasticity of …
mechanical properties such as its stiffness and viscosity. Understanding the viscoelasticity of …