Cellular hypoxia, detectable in up to 80% of non-small cell lung carcinoma (NSCLC) tumors,
is a known cause of radioresistance. High linear energy transfer (LET) particle radiation …

Hypoxia-induced radioresistance reduces the efficacy of radiotherapy for solid
malignancies, including non-small cell lung cancer (NSCLC). Cellular hypoxia can confer …

Radiation is one of the main treatment modalities in lung cancer, but low sensitivity and
acquired resistance of lung cancer cells to radiation frequently result in treatment failure. The …

Purpose It is reported inflammatory cytokine interleukin-8 (IL-8) could predict radiation-
induced lung toxicity (RILT). RILT is believed to be a consequence of a cascade of cytokine …

Background Solid tumors are often riddled with hypoxic areas, which develops as a result of
high proliferation. Cancer cells willingly adapt and thrive in hypoxia by activating complex …

Nuclear factor (NF)-κB is a transcription factor that plays significant role in immunity, cellular
survival and inhibition of apoptosis, through the induction of genetic networks. Depending …

Background Tumor hypoxia, one of the features of solid tumors, is associated with chemo-
resistance. Recently, nuclear factor-κB (NF-κB) was found to be activated during hypoxia …

Purpose: To characterize the cellular distribution and DNA binding activity of the nuclear
factor kappaB (NF‐κ B) in a model of radiation‐induced lung damage in the rat. Materials …

Radiation modulates both tumor cells and immune cells in the tumor microenvironment to
exert its anti-tumor activity; however, the molecular connection between tumor cells and …

The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (E‐TKI) resistance
has emerged as an important clinical issue. To overcome this resistance, researchers have …