Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …

Protein kinase A (PKA) is activated during sympathetic stimulation of the heart and
phosphorylates key proteins involved in cardiac Ca2+ handling, including the L-type Ca2+ …

L-type Ca channels (LTCC), which play a key role in cardiac excitation–contraction coupling,
are located predominantly at the transverse (t-) tubules in ventricular myocytes. Caveolae …

Activation of β-adrenergic receptors and consequent phosphorylation by cAMP-dependent
protein kinase A (PKA) greatly increases the L-type Ca2+ current through CaV1. 2 channels …

Heart failure is a complex clinical syndrome, represented as an impairment in ventricular
filling and myocardial blood ejection. As such, heart failure is one of the leading causes of …

Compartmentalization of cAMP-dependent protein kinase A (PKA) by A-kinase anchoring
proteins (AKAPs) targets PKA to distinct subcellular locations in many cell types. However …

The β‐adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates
heart rate and contractility. Here, we identified a supramolecular complex consisting of the …

Rationale: Adenylyl cyclase (AC) represents one of the principal molecules in the β-
adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second …

A kinase anchoring proteins (AKAPs) compose a growing list of diverse but functionally
related proteins defined by their ability to bind to the regulatory subunit of protein kinase A …

Regulation of Ca V 1.2 channels in cardiac myocytes by the β-adrenergic pathway requires
a signaling complex in which the proteolytically processed distal C-terminal domain acts as …