Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …
Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration
In vivo intracellular recordings of hippocampal neurons reveal the occurrence of fast events
of small amplitude called spikelets or fast prepotentials. Because intracellular recordings …
of small amplitude called spikelets or fast prepotentials. Because intracellular recordings …
Optogenetic dissection of entorhinal-hippocampal functional connectivity
Introduction The mammalian space circuit contains several functionally specialized cell
types, such as place cells in the hippocampus and grid cells, head direction cells, and …
types, such as place cells in the hippocampus and grid cells, head direction cells, and …
Cortical layer–specific critical dynamics triggering perception
INTRODUCTION Perceptual experiences in mammals may arise from patterns of neural
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …
Long-range–projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex
S Melzer, M Michael, A Caputi, M Eliava, EC Fuchs… - Science, 2012 - science.org
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory.
The two forebrain regions are highly interconnected via excitatory pathways. Using …
The two forebrain regions are highly interconnected via excitatory pathways. Using …
Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons
Information processing in neuronal networks involves the recruitment of selected neurons
into coordinated spatiotemporal activity patterns. This sparse activation results from …
into coordinated spatiotemporal activity patterns. This sparse activation results from …
Awake hippocampal sharp-wave ripples support spatial memory
The hippocampus is critical for spatial learning and memory. Hippocampal neurons in
awake animals exhibit place field activity that encodes current location, as well as sharp …
awake animals exhibit place field activity that encodes current location, as well as sharp …
Hippocampal place fields emerge upon single-cell manipulation of excitability during behavior
The origin of the spatial receptive fields of hippocampal place cells has not been
established. A hippocampal CA1 pyramidal cell receives thousands of synaptic inputs …
established. A hippocampal CA1 pyramidal cell receives thousands of synaptic inputs …
Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences
AD Grosmark, G Buzsáki - Science, 2016 - science.org
Cell assembly sequences during learning are “replayed” during hippocampal ripples and
contribute to the consolidation of episodic memories. However, neuronal sequences may …
contribute to the consolidation of episodic memories. However, neuronal sequences may …
Correlated bursts of activity in the neonatal hippocampus in vivo
X Leinekugel, R Khazipov, R Cannon, H Hirase… - Science, 2002 - science.org
The behavior of immature cortical networks in vivo remains largely unknown. Using multisite
extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized …
extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized …