Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics

M Valero, I Zutshi, E Yoon, G Buzsáki - Science, 2022 - science.org
Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires
monitoring their subthreshold behavior. We probed the subthreshold dynamics using …

Impact of spikelets on hippocampal CA1 pyramidal cell activity during spatial exploration

J Epsztein, AK Lee, E Chorev, M Brecht - Science, 2010 - science.org
In vivo intracellular recordings of hippocampal neurons reveal the occurrence of fast events
of small amplitude called spikelets or fast prepotentials. Because intracellular recordings …

Optogenetic dissection of entorhinal-hippocampal functional connectivity

SJ Zhang, J Ye, C Miao, A Tsao, I Cerniauskas… - Science, 2013 - science.org
Introduction The mammalian space circuit contains several functionally specialized cell
types, such as place cells in the hippocampus and grid cells, head direction cells, and …

Cortical layer–specific critical dynamics triggering perception

JH Marshel, YS Kim, TA Machado, S Quirin, B Benson… - Science, 2019 - science.org
INTRODUCTION Perceptual experiences in mammals may arise from patterns of neural
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …

Long-range–projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex

S Melzer, M Michael, A Caputi, M Eliava, EC Fuchs… - Science, 2012 - science.org
The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory.
The two forebrain regions are highly interconnected via excitatory pathways. Using …

Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons

A Hodapp, ME Kaiser, C Thome, L Ding, A Rozov… - Science, 2022 - science.org
Information processing in neuronal networks involves the recruitment of selected neurons
into coordinated spatiotemporal activity patterns. This sparse activation results from …

Awake hippocampal sharp-wave ripples support spatial memory

SP Jadhav, C Kemere, PW German, LM Frank - Science, 2012 - science.org
The hippocampus is critical for spatial learning and memory. Hippocampal neurons in
awake animals exhibit place field activity that encodes current location, as well as sharp …

Hippocampal place fields emerge upon single-cell manipulation of excitability during behavior

D Lee, BJ Lin, AK Lee - Science, 2012 - science.org
The origin of the spatial receptive fields of hippocampal place cells has not been
established. A hippocampal CA1 pyramidal cell receives thousands of synaptic inputs …

Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences

AD Grosmark, G Buzsáki - Science, 2016 - science.org
Cell assembly sequences during learning are “replayed” during hippocampal ripples and
contribute to the consolidation of episodic memories. However, neuronal sequences may …

Correlated bursts of activity in the neonatal hippocampus in vivo

X Leinekugel, R Khazipov, R Cannon, H Hirase… - Science, 2002 - science.org
The behavior of immature cortical networks in vivo remains largely unknown. Using multisite
extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized …