Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian
conditioned approach behavior directed at the conditioned stimulus. The study examined …

Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …

Rationale Relapse often occurs when individuals are exposed to stimuli or cues previously
associated with the drug-taking experience. The ability of drug cues to trigger relapse is …

Sign-tracking is a well-known phenomenon in appetitive Pavlovian conditioning in which
subjects approach the site of a conditioned stimulus (CS) associated with an appetitive …

Relapse into addiction is often triggered by cues that have a Pavlovian association with
drugs and drug-taking. Sign-tracking involves approach of and interaction with Pavlovian …

Memantine is a drug which has antagonistic effects at N-methyl-D-aspartate and 5-
hydroxytryptamine 3 receptors. Its properties may make it especially effective at reducing …

Relapse-like behaviors have been measured in animals using the Pavlovian conditioned
approach (PCA) model. During conditioning, a reward is paired with a novel, neutral cue …

The attribution of incentive-motivational value to drug-related cues underlies relapse and
craving in drug addiction. One method of addiction treatment, cue-exposure therapy, utilizes …

Addiction is characterized as a chronic debilitating disease. One devastating feature of
addiction is the susceptibility of relapse (40–60%) after stretches of abstinence. One theory …

Pavlovian learning processes can render cues and contexts associated with drug-taking
experiences into powerful motivators, such that exposure to such stimuli can elicit drug …