During pregnancy, there are several physiological changes during each trimester that can
affect the absorption, distribution, metabolism, and elimination of drugs. Although there is a …

Pregnancy is associated with a variety of physiological changes that can alter the
pharmacokinetics and pharmacodynamics of several drugs. However, limited data exists on …

Pregnancy is a complex state where changes in maternal physiology have evolved to favor
the development and growth of the placenta and the fetus. These adaptations may affect …

Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes
during pregnancy may significantly alter the overall systemic drug exposure, necessitating …

As pregnant individuals have traditionally been excluded from clinical trials, there is a gap in
knowledge at the time of drug approval regarding safety, efficacy, and appropriate dosing for …

Background: More than 90% of pregnant women take at least one drug during pregnancy.
Drug dose adjustments during pregnancy are sometimes necessary due to various …

The use of prescribed and over-the-counter medications in pregnancy is on the rise. Many
women become pregnant at an older age and with preexisting medical conditions that …

Epidemiologic surveys have determined that between one third and two thirds of all
pregnant women will take at least one medication during pregnancy (1–5). These data …

Most of the interventions performed by obstetric providers involve the administration of
drugs. Pregnant patients are pharmacologically and physiologically different from …

Drug therapy in pregnancy may cause anxiety to both physicians and patients due to
uncertainty regarding dosing and safety. Nevertheless, the need for medication is high given …