Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids

JLS Santos, CA Araújo, CAG Rocha, ZSM Costa-Ferro… - Biomolecules, 2023 - mdpi.com
Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders
that affect communication and social interactions and present with restricted interests and …

Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction

A Cheffer, LJ Flitsch, T Krutenko, P Röderer… - Molecular Autism, 2020 - Springer
The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a
unique opportunity to study early stages of human central nervous system development …

Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations

S Kilpatrick, C Irwin, KK Singh - Translational Psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder caused by
genetic or environmental perturbations during early development. Diagnoses are dependent …

Patient-derived induced pluripotent stem cells (iPSCs) and cerebral organoids for drug screening and development in autism spectrum disorder: opportunities and …

C Villa, R Combi, D Conconi, M Lavitrano - Pharmaceutics, 2021 - mdpi.com
Autism spectrum disorder (ASD) represents a group of neurodevelopmental diseases
characterized by persistent deficits in social communication, interaction, and repetitive …

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

DS Kim, PJ Ross, K Zaslavsky, J Ellis - Frontiers in cellular …, 2014 - frontiersin.org
Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder
characterized by deficits in social communication, and restricted and repetitive patterns of …

Modeling developmental brain diseases using human pluripotent stem cells-derived brain organoids–progress and perspective

A Bhattacharya, WWY Choi, J Muffat, Y Li - Journal of Molecular Biology, 2022 - Elsevier
Developmental brain diseases encompass a group of conditions resulting from genetic or
environmental perturbations during early development. Despite the increased research …

Modeling autism spectrum disorders with human neurons

PCB Beltrão-Braga, AR Muotri - Brain research, 2017 - Elsevier
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized
by impaired social communication and interactions and by restricted and repetitive …

The use of iPSC technology for modeling Autism Spectrum Disorders

FB Russo, A Brito, AM de Freitas, A Castanha… - Neurobiology of …, 2019 - Elsevier
Abstract Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders
that influence social skills, involving communication, interaction, and behavior, usually with …

Psychiatry in a dish: stem cells and brain organoids modeling autism spectrum disorders

M Ilieva, ÅF Svenningsen, M Thorsen, TM Michel - Biological psychiatry, 2018 - Elsevier
Autism spectrum disorders are a group of pervasive neurodevelopmental conditions with
heterogeneous etiology, characterized by deficits in social cognition, communication, and …

[HTML][HTML] The use of induced pluripotent stem cell technology to advance autism research and treatment

A Acab, AR Muotri - Neurotherapeutics, 2015 - Elsevier
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders sharing a core set of symptoms, including impaired social interaction, language …