Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

Hypoxia inducible factor (HIF) is an oxygen-sensitive transcription factor that enables
aerobic organisms to adapt to hypoxia. This is achieved through the transcriptional …

The hypoxia-inducible factor (HIF) system was discovered as an oxygen-sensitive regulatory
pathway that confers adaptive responses to hypoxia. Novel aspects of this growing network …

Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular
response to hypoxia. There is a great body of evidence supporting the protective role of HIF …

The circulatory system distributes blood flow to each tissue and transports oxygen and
nutrients. Peripheral circulation is required to maintain the physiological function in each …

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …

Cardiovascular (CV) diseases are the major cause of death in industrialized countries. The
main function of the CV system is to deliver nutrients and oxygen to all tissues. During most …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …