Genetics of coronary artery disease: discovery, biology and clinical translation

AV Khera, S Kathiresan - Nature Reviews Genetics, 2017 - nature.com
Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants

S Sayols-Baixeras, C Lluís-Ganella… - The application of …, 2014 - Taylor & Francis
Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and
its prevalence is expected to increase in the coming years. CAD events are caused by the …

[PDF][PDF] Genetics of common, complex coronary artery disease

K Musunuru, S Kathiresan - Cell, 2019 - cell.com
Coronary artery disease represents the leading cause of death worldwide, sparing no
nation, ethnicity, or economic stratum. Coronary artery disease is partly heritable. While …

Mechanisms of disease: The genetic basis of coronary heart disease

IJ Kullo, K Ding - Nature Clinical Practice Cardiovascular Medicine, 2007 - nature.com
Since completion of the human genome sequence, considerable progress has been made
in determining the genetic basis of human diseases. Understanding the genetic basis of …

Genes and coronary artery disease: where are we?

R Roberts, AFR Stewart - Journal of the American College of Cardiology, 2012 - jacc.org
Susceptibility to coronary artery disease (CAD) is claimed to be 40% to 60% inherited, but
until recently genetic risk factors predisposing to CAD have been elusive. Comprehensive …

Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour

JF Peden, M Farrall - Human molecular genetics, 2011 - academic.oup.com
Coronary artery disease (CAD) is the leading cause of death worldwide. Affected individuals
cluster in families in patterns that reflect the sharing of numerous susceptibility genes …

A decade of genome-wide association studies for coronary artery disease: the challenges ahead

J Erdmann, T Kessler, L Munoz Venegas… - Cardiovascular …, 2018 - academic.oup.com
In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …

Genetics of coronary artery disease and myocardial infarction-2013

T Kessler, J Erdmann, H Schunkert - Current cardiology reports, 2013 - Springer
Coronary artery disease is a complex disease influenced by modifiable risk factors as well
as genetic susceptibility. The genetics of coronary artery disease and myocardial infarction …

Molecular genetics of coronary artery disease

Q Wang - Current opinion in cardiology, 2005 - journals.lww.com
Genetic studies provide new insights into the pathogenesis of coronary artery disease and
myocardial infarction. Future studies will focus on identification of new disease-causing …

Genetics of coronary artery disease

K Musunuru, S Kathiresan - Annual review of genomics and …, 2010 - annualreviews.org
Coronary artery disease and its clinical manifestations, including myocardial infarction, are
heritable traits, consistent with a role for inherited DNA sequence variation in conferring risk …