Distinct functions of parvalbumin and somatostatin interneurons in the anterior cingulate cortex result in heterogeneity of social interaction impairments

S Wu, C Qi, W Sima, H Miao, E Hu, J Ge, M Deng… - 2024 - researchsquare.com
The anterior cingulate cortex (ACC) serves as a core region in social networks, and
impairments in this area have been identified in autism spectrum disorders. Our prior …

Gradient of parvalbumin-and somatostatin-expressing interneurons across cingulate cortex is differentially linked to aggression and sociability in BALB/cJ mice

S Van Heukelum, F Mogavero, MAE Van de Wal… - Frontiers in …, 2019 - frontiersin.org
Successfully navigating social interactions requires the precise and balanced integration of
social and environmental cues. When such flexible information integration fails, maladaptive …

Social stimulus causes aberrant activation of the medial prefrontal cortex in a mouse model with autism-like behaviors

A Pirone, JM Alexander, JB Koenig… - Frontiers in synaptic …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is a highly prevalent and genetically heterogeneous brain
disorder. Developing effective therapeutic interventions requires knowledge of the brain …

Investigations of the role of the basolateral amygdala-nucleus accumbens circuit and endocannabinoid regulation of social interaction behavior in the Shank3B …

OM Folkes - 2020 - ir.vanderbilt.edu
Deficits in social interaction (SI) are a core symptom of Autism Spectrum Disorders (ASD),
however treatments for social deficits are notably lacking. Elucidating brain circuits and …

Developmental progression of prefrontal circuit dysfunction in a Shank3-/-mouse model of autism spectrum disorder

G Devienne, G Vantomme, J Huguenard - bioRxiv, 2024 - biorxiv.org
Autism Spectrum Disorders (ASD) are a group of neurodevelopmental disorders with
heterogeneous causes, characterized by communication deficits, impaired social …

Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice

KA Han, TH Yoon, J Shin, JW Um, J Ko - Molecular Autism, 2020 - Springer
Background Recent progress in genomics has contributed to the identification of a large
number of autism spectrum disorder (ASD) risk genes, many of which encode synaptic …

The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder

AN Mohapatra, S Wagner - Frontiers in Psychiatry, 2023 - frontiersin.org
Social interaction is a complex behavior which requires the individual to integrate various
internal processes, such as social motivation, social recognition, salience, reward, and …

Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder

M Matthiesen, A Khlaifia, CFD Steininger Jr… - Molecular Brain, 2023 - Springer
Social behavior emerges early in development, a time marked by the onset of
neurodevelopmental disorders featuring social deficits, including autism spectrum disorder …

Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder

NY Ahmed, R Knowles, L Liu, Y Yan, X Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Interneurons are fundamental cells for maintaining the excitation-inhibition balance in the
brain in health and disease. While interneurons have been shown to play a key role in the …

Reduced excitatory activity in the developing mPFC mediates a PVH-to-PVL transition and impaired social cognition in autism spectrum disorders

Y Luo, L Wang, Y Cao, Y Shen, Y Gu, L Wang - Translational Psychiatry, 2024 - nature.com
Understanding the neuropathogenesis of impaired social cognition in autism spectrum
disorders (ASD) is challenging. Altered cortical parvalbumin-positive (PV+) interneurons …