Effects of Central α7 Nicotinic Acetylcholine Receptors on Energy Intake and Body Weight in Rats

AM DiBrog - 2020 - search.proquest.com
Obesity is a prevalent disease, but effective treatments remain limited. Agonists of the alpha-
7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but …

Effects of Alpha-7 Nicotinic Acetylcholine Receptor Agonism on Feeding in Rats

AM DiBrog - 2023 - search.proquest.com
Obesity is an exponentially increasing disease, yet limited treatment options remain
available. Agonists of the alpha-7 nicotinic acetylcholine receptor (α7nAChR) have been …

The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 does not affect food intake in rats

AM DiBrog, KA Kern, A Mukherjee, JT Przybysz… - Pharmacology …, 2022 - Elsevier
Obesity is a prevalent disease, but effective treatments remain limited. Agonists of the alpha-
7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in mice, but …

The alpha-7 nicotinic acetylcholine receptor agonist PHA-543613 reduces food intake in male rats

AM DiBrog, KA Kern, E Demieri… - Pharmacology …, 2024 - Elsevier
Obesity is a prevalent disease, but effective treatment options remain limited. Agonists of the
alpha-7 nicotinic acetylcholine receptor (α7nAChR) promote negative energy balance in …

α4β2 nicotinic acetylcholine receptors intrinsically influence body weight in mice

G Dezfuli, TT Olson, LM Martin, Y Keum, BA Siegars… - …, 2020 - Elsevier
Desensitization of the nicotinic acetylcholine receptor (nAChR) containing the β2 subunit is
a potentially critical mechanism underlying the body weight (BW) reducing effects of …

Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

H Xie, N Yepuri, Q Meng, R Dhawan, CA Leech… - Reviews in Endocrine …, 2020 - Springer
The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic
regulatory mechanism for sensing and controlling the body's response to inflammatory …

Nicotinic α4 receptor-mediated cholinergic influences on food intake and activity patterns in hypothalamic circuits

AP García, T Aitta-aho, L Schaaf, N Heeley… - PLoS …, 2015 - journals.plos.org
Nicotinic acetylcholine receptors (nAChRs) play an important role in regulating appetite and
have been shown to do so by influencing neural activity in the hypothalamus. To shed light …

[HTML][HTML] The role of alpha-7 nicotinic receptors in food intake behaviors

KL McFadden, MA Cornier, JR Tregellas - Frontiers in psychology, 2014 - frontiersin.org
Nicotine alters appetite and energy expenditure, leading to changes in body weight. While
the exact mechanisms underlying these effects are not fully established, both central and …

The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db …

Q Meng, OG Chepurny, CA Leech… - Diabetes, Obesity …, 2022 - Wiley Online Library
Aim To establish if alpha‐7 nicotinic acetylcholine receptor (α7nAChR) agonist GTS‐21
exerts a blood glucose‐lowering action in db/db mice, and to test if this action requires …

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice

E Somm, A Guérardel, K Maouche, A Toulotte… - Molecular genetics and …, 2014 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated cation channels
well characterized in neuronal signal transmission. Moreover, recent studies have revealed …