During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to
restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this …

Histone chaperones are at the hub of a diverse interaction networks integrating a plethora of
chromatin modifying activities. Histone H3/H4 chaperone ASF1 is a target for cell-cycle …

Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome
maintenance and proper cell division in animals and plants. A major function of TLKs is to …

Abstract Background The Tousled Like Kinases (TLKs) are involved in chromatin dynamics,
including DNA replication and repair, transcription, and chromosome segregation. Indeed …

To restore chromatin on new DNA during replication, recycling of histones evicted ahead of
the fork is combined with new histone deposition. The Asf1 histone chaperone, which buffers …

First described in Arabidopsis thaliana [1], Tousled-like kinases (Tlks) are highly conserved
in both plants and animals. In plants, Tousled kinase is essential for proper flower and leaf …

DNA sequence and epigenetic information embedded in chromatin must be faithfully
duplicated and transmitted to daughter cells during cell division. However, how chromatin …

Tousled-like kinases (TLKs) constitute a family of serine/threonine kinases conserved in
plants and animals that act in a cell cycle-dependent manner. In mammals, their activity …

The packaging of the eukaryotic genome into chromatin is likely to regulate all processes
that occur on the DNA template. The assembly and disassembly of chromatin structures from …

Maintenance of chromosomal integrity requires tight coordination of histone biosynthesis
with DNA replication. Here, we show that extracts from human cells exposed to replication …