Basophil activation test: food challenge in a test tube or specialist research tool?

AF Santos, G Lack - Clinical and translational allergy, 2016 - Springer
Oral food challenge (OFC) is the gold-standard to diagnose food allergy; however, it is a
labour and resource-intensive procedure with the risk of causing an acute allergic reaction …

Road map for the clinical application of the basophil activation test in food allergy

AF Santos, WG Shreffler - Clinical & Experimental Allergy, 2017 - Wiley Online Library
The diagnosis of IgE‐mediated food allergy based solely on the clinical history and the
documentation of specific IgE to whole allergen extract or single allergens is often …

Basophil activation test: mechanisms and considerations for use in clinical trials and clinical practice

AF Santos, O Alpan, HJ Hoffmann - Allergy, 2021 - Wiley Online Library
The basophil activation test (BAT) is a functional assay that measures the degree of
degranulation following stimulation with allergen or controls by flow cytometry. It correlates …

Basophil activation test in allergy: time for an update?

S Chirumbolo - International archives of allergy and immunology, 2012 - karger.com
A wide range of reported evidence in the literature has shown that the quantification of
basophil activation by flow cytometry (basophil activation test, BAT) has proven to be a …

The basophil activation test for clinical management of food allergies: recent advances and future directions

D Briceno Noriega, M Teodorowicz… - Journal of Asthma …, 2021 - Taylor & Francis
The basophil activation test (BAT) is an ex vivo functional assay that measures by flow
cytometry the degree of basophil degranulation after stimulation with an allergen. In recent …

Basophil activation test: old and new applications in allergy

O Hemmings, M Kwok, R McKendry… - Current allergy and asthma …, 2018 - Springer
Abstract Purpose of Review The basophil activation test (BAT) using flow cytometry has
supplanted traditional methods of measuring basophil degranulation using histamine and …

The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease

HJ Hoffmann, AF Santos, C Mayorga, A Nopp… - Allergy, 2015 - Wiley Online Library
The basophil activation test (BAT) has become a pervasive test for allergic response through
the development of flow cytometry, discovery of activation markers such as CD 63 and …

[HTML][HTML] Oral immunotherapy and basophil and mast cell reactivity in food allergy

A Paranjape, M Tsai, K Mukai, RA Hoh… - Frontiers in …, 2020 - frontiersin.org
Basophil activation tests (BATs) can closely monitor, in vitro, a patient's propensity to
develop type I hypersensitivity reactions. Because of their high specificity and sensitivity …

The basophil activation test in the diagnosis of allergy: technical issues and critical factors

GJ Sturm, B Kranzelbinder, EM Sturm, A Heinemann… - Allergy, 2009 - Wiley Online Library
Background: The basophil activation test (BAT) is a widely validated and reliable tool
especially for the diagnosis of hymenoptera venom allergy. Nevertheless, several pitfalls …

Evaluation of basophil activation in food allergy: present and future applications

WG Shreffler - Current opinion in allergy and clinical immunology, 2006 - journals.lww.com
Although in their early stages, direct basophil activation tests may prove to be useful in the
clinic. Indirect basophil activation studies are useful when applied to compare functional …