Metabolic risk factors associated with sudden cardiac death (SCD) during acute myocardial ischemia

D Wang, X Wang, J Wu, R Su, J Kong… - Forensic sciences …, 2017 - academic.oup.com
Sudden cardiac death (SCD) is the leading cause of death worldwide. Myocardial ischemia
(MI) is the most common underlying causal disorder for SCD. Metabolic risks leading to SCD …

Metabolic characterization of myocardial infarction using GC-MS-based tissue metabolomics

X Wang, D Wang, J Wu, X Yu, J Lv, J Kong… - International heart …, 2017 - jstage.jst.go.jp
Understanding the metabolic features of myocardial infarction (MI) is critical to its prevention
and treatment. Here, we aimed to characterize the metabolic features of early MI using a …

Non-targeted metabolomics identified a common metabolic signature of lethal ventricular tachyarrhythmia (LVTA) in two rat models

X Wang, D Wang, X Yu, G Zhang, J Wu, G Zhu… - Molecular …, 2016 - pubs.rsc.org
Lethal ventricular tachyarrhythmia (LVTA) is the predominant underlying mechanism of
sudden cardiac death (SCD). The aim of this study is to characterize the metabolic features …

Combined metabolomics and machine learning algorithms to explore metabolic biomarkers for diagnosis of acute myocardial ischemia

J Cao, J Li, Z Gu, J Niu, G An, Q Jin, Y Wang… - International Journal of …, 2023 - Springer
Acute myocardial ischemia (AMI) remains the leading cause of death worldwide, and the
post-mortem diagnosis of AMI represents a current challenge for both clinical and forensic …

Forensic identification of sudden cardiac death: a new approach combining metabolomics and machine learning

J Cao, X Wei, MF Liu, GS An, J Li, QX Du… - Analytical and …, 2023 - Springer
The determination of sudden cardiac death (SCD) is one of the difficult tasks in the forensic
practice, especially in the absence of specific morphological changes in the autopsies and …

Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia

S Chacko, MA Mamas, M El-Omar, D Simon, S Haseeb… - Metabolomics, 2021 - Springer
Introduction Acute myocardial ischaemia and the transition from reversible to irreversible
myocardial injury are associated with abnormal metabolic patterns. Advances in …

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

M Shoaib, RC Choudhary, J Choi, N Kim… - Scientific reports, 2020 - nature.com
Cardiac arrest (CA) is a leading cause of death and there is a necessity for animal models
that accurately represent human injury severity. We evaluated a rat model of severe CA …

Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia–Reperfusion

E Goetzman, Z Gong, D Rajasundaram… - International Journal of …, 2022 - mdpi.com
Acute myocardial infarction (MI) is one of the leading causes of death worldwide. Early
identification of ischemia and establishing reperfusion remain cornerstones in the treatment …

Effects of myocardial ischemia/reperfusion injury on plasma metabolomic profile during aging

C de Lucia, M Piedepalumbo, L Wang… - Aging …, 2021 - Wiley Online Library
Background Heart disease is a frequent cause of hospitalization and mortality for elderly
patients. A common feature of both heart disease and aging itself is the involvement of …

Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary …

A Surendran, M Aliani, A Ravandi - Scientific reports, 2019 - nature.com
Aim: The aim of the study was to discover the metabolomic changes in plasma that occur
during human Ischemia-Reperfusion (I/R) injury and to evaluate the diagnostic utility of …