Highlights•Diverse animal models of depression and anxiety have impaired neurogenesis.•
Neurogenesis is consistently boosted by antidepressants in animal models when animals …

There is growing evidence that stress causes a decrease of neurogenesis in the dentate
gyrus and antidepressant treatment in turn stimulates the cell proliferation in the dentate …

The discovery of newborn neurons in the adult brain has generated enormous interest over
the past decade. Although this process is well documented in the hippocampus and …

Hypotheses are scaffoldings erected in front of a building and then dismantled when the
building is finished. They are indispensable for the workman; but you mustn't mistake the …

Neurogenesis (the birth of new neurons) continues postnatally and into adulthood in the
brains of many animal species, including humans. This is particularly prominent in the …

Since its discovery in mammals, adult neurogenesis, the process of generating functional
neurons from neural progenitor cells in the adult brain, has inspired numerous animal …

The neurogenesis hypothesis of depression was originally formed upon the demonstration
that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work …

There is a growing body of evidence that neural stem cells reside in the adult central
nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns …

Readers of this journal are likely to agree with three statements. First, it is impossible to think
effectively about depression outside the context of biology. Second, it is impossible to think …

Preclinical and clinical studies have demonstrated that stress or depression can lead to
atrophy and cell loss in limbic brain structures that are critically involved in depression …