Conspectus Atropisomerism is a conformational chirality that occurs when there is hindered
rotation about a σ-bond. While atropisomerism is exemplified by biaryls, it is observed in …

An underlying goal of drug discovery is to develop safe and stable substances that
specifically target essential elements that cause disease. Molecular chirality adds an …

Atropisomerism is a stereochemical behavior portrayed by three-dimensional molecules that
bear rotationally restricted σ bond. Akin to the well-represented point-chiral molecules …

Atropisomerism is stereochemistry arising from restricted bond rotation that creates a chiral
axis. Atropisomers are subject to time-dependent inversion of chirality via bond rotation, a …

Atropisomerism is a dynamic type of axial chirality that is ubiquitous in medicinal chemistry.
There are several examples of stable atropisomeric US FDA-approved drugs and …

A modern course of stereochemistry might shock Louis Pasteur, Jacobus Henricus van't
Hoff, Joseph Lebel, Lord Kelvin, Charlotte Finch Roberts, and many other pioneers of the …

Many biologically active molecules exist as rapidly interconverting atropisomeric mixtures.
Whereas one atropisomer inhibits the desired target, the other can lead to off‐target effects …

Conspectus Atropisomerism is a stereochemical phenomenon exhibited by molecules
containing a rotationally restricted σ bond. Contrary to classical point chirality, the two …

Axially chiral compounds have been always considered a laboratory curiosity with rare
prospects of being applied in asymmetric synthesis. Things have changed very quickly in the …

Conspectus Atropisomerism is a type of axial chirality resulting from hindered rotation about
a σ bond that gives rise to nonsuperimposable stereoisomers (termed “atropisomers”). The …