Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Heightened morbidity and mortality in pulmonary tuberculosis (TB) are consequences of
complex disease processes triggered by the causative agent, Mycobacterium tuberculosis …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …

The granuloma is the defining feature of the host response to infection with Mycobacterium
tuberculosis (Mtb). Despite knowing of its existence for centuries, much remains unclear …

Tuberculosis (TB) is a complex disease, and the success of the bacterium as an intracellular
pathogen is the outcome of its close and longstanding coevolution with the mammalian host …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Latent Mycobacterium tuberculosis infection (LTBI) and active tuberculosis (TB) are 2 ends
of a spectrum of states ranging from asymptomatic infection to overt disease. While …

Host–pathogen interactions in tuberculosis should be studied at the disease site because
Mycobacterium tuberculosis is predominately contained in local tissue lesions. Although M …