Myco-fabricated ZnO nanoparticles ameliorate neurotoxicity in mice model of Alzheimer's disease via acetylcholinesterase inhibition and oxidative stress reduction

HA Abd Elmonem, RM Morsi, DS Mansour… - BioMetals, 2023 - Springer
Alzheimer's disease (AD) is one of the primary health problems linked to the decrease of
acetylcholine in cholinergic neurons and elevation in oxidative stress. Myco-fabrication of …

Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

E Yadav, P Yadav - Environmental toxicology, 2021 - Wiley Online Library
Current work was designed to explore the effect of ZnO nanoparticles (ZnONP) biofabricated
by using Trianthema portulacastrum (TP) leaves extract on mice brain hippocampus. ZnO …

Exploring the neuroprotective potential of rosiglitazone embedded nanocarrier system on streptozotocin induced mice model of Alzheimer's disease

S KC, V Kakoty, S Marathe, D Chitkara, R Taliyan - Neurotoxicity research, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an
individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus …

Behavioral effects of zinc oxide nanoparticles on the brain of rats

A Rahdar, MR Hajinezhad, M Bilal, F Askari… - Inorganic Chemistry …, 2020 - Elsevier
Recent studies showed that zinc oxide nanoparticles (ZnO-NPs) can cause toxic damage to
the central nervous system (CNS) after intraperitoneal injection; however, the behavioral …

Zinc oxide nanoparticles induce autophagy and apoptosis via oxidative injury and pro-inflammatory cytokines in primary astrocyte cultures

WJ Song, MS Jeong, DM Choi, KN Kim, MB Wie - Nanomaterials, 2019 - mdpi.com
The present study examined the potential toxic concentrations of zinc oxide nanoparticles
(ZnO NPs) and associated autophagy and apoptosis-related injuries in primary neocortical …

Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction

L Tian, B Lin, L Wu, K Li, H Liu, J Yan, X Liu, Z Xi - Scientific reports, 2015 - nature.com
This study mainly investigated the neurotoxicity induced by zinc oxide nanoparticle (ZnO
NP) in different-aged mice and the interaction between age and ZnO NP exposure. Sixty …

Neuroprotective Effect of New Nanochelating-Based Nano Complex, ALZc3, Against Aβ (1–42)-Induced Toxicity in Rat: a Comparison with Memantine

R Karimi-Sales, M Ashiri, M Hafizi, S Kalanaky… - Pharmaceutical …, 2020 - Springer
Purpose The current drugs for Alzheimer's disease (AD) are only used to slow or delay the
progression of the pathology. So using a novel technology is a necessity to synthesize more …

Synthesis of biocompatible zinc oxide (ZnO) nanoparticles and their neuroprotective effect of 6-OHDA induced neural damage in SH-SY 5Y cells

X Ding, K Lin, Y Li, M Dang, L Jiang - Journal of Cluster Science, 2020 - Springer
Biocompatible zinc oxide nanoparticles were prepared using a simple co-precipitation
method. Through this method, the synthesized zinc oxide nanoparticles that are of uniform …

Chemical and green ZnO nanoparticles ameliorated adverse effects of cisplatin on histological structure, antioxidant defense system and neurotrophins expression in …

NE Majd, MR Tabandeh, S Hosseinifar… - Journal of chemical …, 2021 - Elsevier
Cisplatin (CP) is a chemotherapy agent used in the treatment of cancer, but it has various
side effects, in particular, neurotoxicity. Zinc oxide nanoparticles (ZnO NPs) are a potent …

Zinc oxide nanoparticle induces microglial death by NADPH-oxidase-independent reactive oxygen species as well as energy depletion

AK Sharma, V Singh, R Gera, MP Purohit… - Molecular …, 2017 - Springer
Zinc oxide nanoparticle (ZnO-NP) is one of the most widely used engineered nanoparticles.
Upon exposure, nanoparticle can eventually reach the brain through various routes, interact …