Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most
commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human …

Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and
intellectual disability are thought to arise largely from disruption of excitatory/inhibitory …

Mutations in the X-linked gene, methyl-CpG binding protein 2 (Mecp2), underlie a wide
range of neuropsychiatric disorders, most commonly, Rett Syndrome (RTT), a severe autism …

It is well known that Rett Syndrome, a severe postnatal childhood neurological disorder, is
mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 …

Rett syndrome (RTT) is a neurodevelopmental disorder that represents the most common
genetic cause of severe intellectual disability in females. Most patients carry mutations in the …

Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2.
Complete loss of MECP2 function in males causes congenital encephalopathy …

Background Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause
the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit …

Studies linking mutations in Methyl CpG Binding Protein 2 (MeCP2) to physiological defects
in the neurological disease, Rett syndrome, have focused largely upon neuronal dysfunction …

Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …

Rett syndrome (RTT) is a rare X-linked neurodevelopmental disorder, characterized by
normal post-natal development followed by a sudden deceleration in brain growth with …