[HTML][HTML] Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation
J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang… - Cell reports, 2023 - cell.com
Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most
commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human …
commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human …
Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders
Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and
intellectual disability are thought to arise largely from disruption of excitatory/inhibitory …
intellectual disability are thought to arise largely from disruption of excitatory/inhibitory …
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain
MVC Nguyen, F Du, CA Felice, X Shan… - Journal of …, 2012 - Soc Neuroscience
Mutations in the X-linked gene, methyl-CpG binding protein 2 (Mecp2), underlie a wide
range of neuropsychiatric disorders, most commonly, Rett Syndrome (RTT), a severe autism …
range of neuropsychiatric disorders, most commonly, Rett Syndrome (RTT), a severe autism …
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons
RD Smrt, J Eaves-Egenes, BZ Barkho… - Neurobiology of …, 2007 - Elsevier
It is well known that Rett Syndrome, a severe postnatal childhood neurological disorder, is
mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 …
mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 …
Identification of Region-Specific Cytoskeletal and Molecular Alterations in Astrocytes of Mecp2 Deficient Animals
E Albizzati, E Florio, F Miramondi, I Sormonta… - Frontiers in …, 2022 - frontiersin.org
Rett syndrome (RTT) is a neurodevelopmental disorder that represents the most common
genetic cause of severe intellectual disability in females. Most patients carry mutations in the …
genetic cause of severe intellectual disability in females. Most patients carry mutations in the …
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2.
Complete loss of MECP2 function in males causes congenital encephalopathy …
Complete loss of MECP2 function in males causes congenital encephalopathy …
MeCP2 modulates gene expression pathways in astrocytes
Background Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause
the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit …
the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit …
Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome
Studies linking mutations in Methyl CpG Binding Protein 2 (MeCP2) to physiological defects
in the neurological disease, Rett syndrome, have focused largely upon neuronal dysfunction …
in the neurological disease, Rett syndrome, have focused largely upon neuronal dysfunction …
Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome
BS Johnson, YT Zhao, M Fasolino, JM Lamonica… - Nature medicine, 2017 - nature.com
Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder
characterized by regressive loss of neurodevelopmental milestones and acquired …
characterized by regressive loss of neurodevelopmental milestones and acquired …
Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes
C Delépine, H Meziane, J Nectoux… - Human molecular …, 2016 - academic.oup.com
Rett syndrome (RTT) is a rare X-linked neurodevelopmental disorder, characterized by
normal post-natal development followed by a sudden deceleration in brain growth with …
normal post-natal development followed by a sudden deceleration in brain growth with …